Protein Info for Shew_0980 in Shewanella loihica PV-4

Annotation: multi-sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1171 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details PF02743: dCache_1" amino acids 52 to 252 (201 residues), 45.1 bits, see alignment E=3.7e-15 PF21623: HK_sensor_dom_bact" amino acids 104 to 258 (155 residues), 80.3 bits, see alignment E=5.3e-26 PF00989: PAS" amino acids 369 to 476 (108 residues), 36.3 bits, see alignment E=2.1e-12 TIGR00229: PAS domain S-box protein" amino acids 369 to 485 (117 residues), 44.8 bits, see alignment E=6.5e-16 PF08448: PAS_4" amino acids 373 to 480 (108 residues), 27.5 bits, see alignment E=1.3e-09 PF00512: HisKA" amino acids 511 to 575 (65 residues), 71.6 bits, see alignment 1.9e-23 PF02518: HATPase_c" amino acids 623 to 735 (113 residues), 94.8 bits, see alignment E=1.9e-30 PF00072: Response_reg" amino acids 899 to 1018 (120 residues), 68.6 bits, see alignment E=2.1e-22 PF01627: Hpt" amino acids 1070 to 1135 (66 residues), 36.4 bits, see alignment 2.1e-12

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0980)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QBK3 at UniProt or InterPro

Protein Sequence (1171 amino acids)

>Shew_0980 multi-sensor hybrid histidine kinase (RefSeq) (Shewanella loihica PV-4)
MVRQISRLSSLFGGRSLLLAASMLVLMVALVIIASFESQLNQNIVDGLRSDLEIQSEQVN
NQAQDRLNRYFNNLRFLFETPPISGLSRARNNQGIDPVDETRYDQWRHRLETIFVAFLQN
NREYEQLRILSSDGMELIRVDRRGGAVQVIDDTNLQDKQGRDYFQASKDLQQGEIYTSPI
NLNREFGKIDYPYRPMLRLATPIFDDNGGHFGLLIVNINANALLSSFKRLVPAPIELVLT
DSDGYFLVHPDEEMRFSRDLHPDLVWDKHYQQSKTLKRNFELVLDSYHDNKPYYAYRRAI
TLSNDAQSGRLTATLMAPKQYVQELAVSRRISVYSFMLAVGVLFLFVVIILGRSARSSQA
LAKEKAQSAAIIDGSKDAIIGVGTSGVVNNWNRAAELLFGYDADYAKGHFINQLALLPEV
DLAALVSKANQGNKTLNLDAELPLNEGRIVDLYVSVSPILGENKHALGVAIIIRDVSIEK
QAAKKIQLVNAELEKKVAIRTQELQKASLVKSSFISNISHEMRTPLNGIVGTLNLVRKDS
LTERQARYLEMAEVSVNTLSALINDVLDLSKIEAGKLDLDMSSFNPLNLIESVCSSMAVK
AQEKGIEFVIDVVDLRCQSVDSDPHRITQILTNLINNAIKFTDHGYIKVRAHSRLRETGE
LEFICEVSDTGIGIAEENQAKLFTAFSQATSSIAAQYGGTGLGLSICKELSELLNGKMSF
ESHKGQGSCFIFTMVLHQGEFKLMAPEALLHEMTCSVLLVNEAQQACVEAAIARLGGKLL
PGSPIRDWLNQDAPVPDVLPHVLIVEQRHSLLTDLDSLWPTLTATHKRLPRVLAFQKSAD
GNKALRNIELEYLNNPLLFSEFMQKFGAPKASSGVENVHPQVTPIISEEEAHRIKGARVL
VVDDNEINIEVALGILSELPLEFVRAINGQEALTKLRECEQEGLGVHCILMDCQMPILNG
YDCTRAIRAGEAGEAFVDTPIIAMTASAMMGERDKCIEAGMNDYITKPIVAERLQEKVTD
WLISVCEFGDLPTLVEAAPHEEIQVKDEDYVWNRQLALSRLMNNEVLFAEICQMYHDTSP
AQVGELEEAIAAKDYEKVRQLSHGLKGLSSSIGAIQLQEQFLSLEMEAKMKNCDKLNLLF
GVIKPCYAKLMERLQETLEPKDEVQNASAQT