Protein Info for Shew_0951 in Shewanella loihica PV-4

Annotation: response regulator receiver modulated diguanylate phosphodiesterase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 399 PF00072: Response_reg" amino acids 5 to 120 (116 residues), 49.6 bits, see alignment E=4.3e-17 PF00563: EAL" amino acids 144 to 380 (237 residues), 200 bits, see alignment E=4.1e-63

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0951)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QBH4 at UniProt or InterPro

Protein Sequence (399 amino acids)

>Shew_0951 response regulator receiver modulated diguanylate phosphodiesterase (RefSeq) (Shewanella loihica PV-4)
MSINVLIVDDSLSACRVLSRHFLLLDVDKVEFCRDARSAIRTLSKYSDDYQIVVVDLHMP
EVDGIEFLMRLSKMEFKGGIIIASGMESRIVEAASQLVEASKLRLLGALMKPVTTEQLRV
CVERYRLMAFQGNGVRHKGLMSIDEIRRAINSNKIIPYYQAQVDIASGKIKGFEVLCRLQ
QGTRLQLITPDKFIDVAECNNALNSLTTKLLNNAIPEWALISQFESCKQCHLSINLTPKQ
LNQSGWHTRLMQYCEQNLLSPSRLTVEITENQVLDKQRQHSTISQLRMNRIGVAIDDFGT
GYTNLSQLCTLPISELKLDRSLVHGIHKDPVSQTILKSMQAISGKLGIHLVAEGVEDIHD
LNYLEQIEDISLQGYLICRPKPYSELVRWLKARERLVQA