Protein Info for Shew_0835 in Shewanella loihica PV-4

Annotation: peptidase M1, membrane alanine aminopeptidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 882 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF17900: Peptidase_M1_N" amino acids 52 to 204 (153 residues), 43.7 bits, see alignment E=5e-15 PF01433: Peptidase_M1" amino acids 280 to 467 (188 residues), 64.5 bits, see alignment E=1.7e-21 PF11838: ERAP1_C" amino acids 551 to 860 (310 residues), 86 bits, see alignment E=5.1e-28

Best Hits

KEGG orthology group: K01256, aminopeptidase N [EC: 3.4.11.2] (inferred from 100% identity to slo:Shew_0835)

Predicted SEED Role

"Membrane alanine aminopeptidase N (EC 3.4.11.2)" (EC 3.4.11.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.2

Use Curated BLAST to search for 3.4.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QB59 at UniProt or InterPro

Protein Sequence (882 amino acids)

>Shew_0835 peptidase M1, membrane alanine aminopeptidase (RefSeq) (Shewanella loihica PV-4)
MRLFSLCASLLLCLLIGACQSTSPGSNQRSEKSLGISASVAKQRASRVSQVSYQLHLDLT
QARRFKGEAQIQFQLADTQQALSLDLEQALISQLVINGQKLYPNYDGHTLVIPASLLQGG
ANLIKVDFSSPYSHEDQGLIEFIDPKDGLRYLYSHFLPSSAQTLAPQFDQPDLRASYRLS
VLAPSDWQVASAAKVQSHQPMGESHQALDESRQTVGENHQPAGENSLWQFMQSEPVSPHN
FSLLAGPYQTWQSEAEGIALLLFARQSQAESIDAETWLSQTQQALSHYQQRLGSKYPFGH
YTQAIVPHLPSEFRASQAQTAFDERNLPQGTPRREILRALAEQWLGNLVTLKWWDQLWLN
QSLAYLVADDGEAQLFGQTQADEQQSFIRSPEQVEQQIANSLELFSQDPLPSQNKAIAQL
NQLKFMLGDTNFYQGIGNYLERFALQNADLNDFISSLEQVTKQPLSQWSQAAFKRAGVTR
LEAEFSCAGDRISRFDLKQHNGDLASTQRVKLGLFTLGRHGLHKNLVSEVNYQGASTEVK
RLKGVRCPDLVFSNYQNKAYVRVKLDKASLETALLHLGSLEESDLRRMLWQSLWESVLAG
ELPLPRFIGSTLVNLPAETDPQVLVSAQDQLKQAKALLEQMSPNQQRYSRQALNAIAQMS
LRLTISNKADPALQSLWFDNYLHFAVSHQAKSHLAALLDERESLPGITLTPERRWQIITH
LNRYDYPGSERLLLKEKQKDTSPEGQAAALGALVARPSAKEKRQWFERIQAHSKESDPQL
LEKLTQVMRHLYPSEQKAPSQASAEQRLAELAEVDKRNSQAFMQSYTANLLPRSCSYASL
LRLQALLDKPEGYSPTTLRGINRTIAAEQECIRVQEAMQPNP