Protein Info for Shew_0774 in Shewanella loihica PV-4

Annotation: peptidase S9B dipeptidylpeptidase IV subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00930: DPPIV_N" amino acids 139 to 462 (324 residues), 333.6 bits, see alignment E=4.8e-103 PF02129: Peptidase_S15" amino acids 507 to 663 (157 residues), 37.9 bits, see alignment E=7e-13 PF20434: BD-FAE" amino acids 523 to 708 (186 residues), 34.5 bits, see alignment E=6.2e-12 PF00561: Abhydrolase_1" amino acids 528 to 646 (119 residues), 26.4 bits, see alignment E=2.1e-09 PF01738: DLH" amino acids 548 to 727 (180 residues), 31.8 bits, see alignment E=4.5e-11 PF12146: Hydrolase_4" amino acids 550 to 650 (101 residues), 30.6 bits, see alignment E=8.5e-11 PF00326: Peptidase_S9" amino acids 553 to 749 (197 residues), 195.6 bits, see alignment E=3e-61 PF00756: Esterase" amino acids 607 to 648 (42 residues), 23.6 bits, see alignment 1.7e-08

Best Hits

KEGG orthology group: K01278, dipeptidyl-peptidase 4 [EC: 3.4.14.5] (inferred from 100% identity to slo:Shew_0774)

Predicted SEED Role

"Dipeptidyl peptidase IV"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.14.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QAZ8 at UniProt or InterPro

Protein Sequence (750 amino acids)

>Shew_0774 peptidase S9B dipeptidylpeptidase IV subunit (RefSeq) (Shewanella loihica PV-4)
MTKKWISSALMAVPMFLSHAVSASQPQLAQPVGGNEPLTIERLYASPALAGSSPRGLKLS
PDGKRVTYLAGRAEDQHFYDLWQMEVATGKQSLLLDADKLKSGELSDEEKARRERQRIYG
QGIMEYFWADDSQALLIPASGVLYYYSLSDNKVTPLPVGEGFTTDAKLSPKGHYVSFVRD
QNLYVFDLRTQKLTAMTTDGGGAIKNGMAEFVAQEEMDRMTGYWWAPDESAIAFTRIDES
GVELVTRNEIYADGIKLTEQRYPYAGKNNVAIALGVVTLANKQVRWVDLGEDKDIYLPRV
KWLPDSLQLSFQWQSRDQHRLDLRILDLRSQDAPMTMIREESDAWVNLNNDLYFLKKSPQ
MLWASERDGFNHLYLFDQQGRQLRQLTKGDWAVDELVHVDEQEGWVYFTGRKASVVEQHL
FRVPLKGGKIEQLSKRSGMHAPVFADNQAIYLDYFNSLAQPPQISLHDEQGKRLAWVEQN
QVDKSHPLYPYFGQWQLPEFGQIKAEDGQALQYRLFKPTQFDATKRYPVVVRVYGGPHAQ
LVVNSWSEHDYFTQYLLQQGFIVFQLDNRGSAHRGTKFEQVIYKHLGEAEVNDQKAGVDY
LRSLSYVDGKNIAIYGHSYGGYMALMSLFKAPDYFKAAISGAPVTDWSLYDSHYTERYLS
HPATNAEGYEASSVLPYVKGYQSGLLMYHGMADDNVLFENSTRVYKALQDEGKLFQMIDY
PGSKHSMRGEKVRTHLYRSLADFLDRQLKH