Protein Info for Shew_0459 in Shewanella loihica PV-4

Annotation: PAS/PAC sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1230 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 354 to 373 (20 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 457 to 578 (122 residues), 60.2 bits, see alignment E=1.1e-20 amino acids 581 to 707 (127 residues), 39.8 bits, see alignment E=2.2e-14 PF00989: PAS" amino acids 459 to 568 (110 residues), 47.4 bits, see alignment E=7.4e-16 PF13188: PAS_8" amino acids 459 to 501 (43 residues), 28.8 bits, see alignment (E = 3.5e-10) PF08448: PAS_4" amino acids 464 to 572 (109 residues), 64.2 bits, see alignment E=4.9e-21 PF13426: PAS_9" amino acids 468 to 569 (102 residues), 33.9 bits, see alignment E=1.3e-11 amino acids 605 to 699 (95 residues), 21.9 bits, see alignment 7e-08 PF08447: PAS_3" amino acids 606 to 695 (90 residues), 75 bits, see alignment 1.9e-24 PF00512: HisKA" amino acids 722 to 786 (65 residues), 78.6 bits, see alignment 1.2e-25 PF02518: HATPase_c" amino acids 833 to 947 (115 residues), 93.9 bits, see alignment E=3.5e-30 PF00072: Response_reg" amino acids 970 to 1084 (115 residues), 73.8 bits, see alignment E=4.9e-24 amino acids 1112 to 1223 (112 residues), 98.4 bits, see alignment E=1.1e-31

Best Hits

KEGG orthology group: None (inferred from 100% identity to slo:Shew_0459)

Predicted SEED Role

"Sensory box histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3QA33 at UniProt or InterPro

Protein Sequence (1230 amino acids)

>Shew_0459 PAS/PAC sensor hybrid histidine kinase (RefSeq) (Shewanella loihica PV-4)
MKSTEPDLQLKSPIQKNYNRAVFYTYIGVIIMALLTAWIFFERQKTQMMDQREELVERHV
LQIDLLLESSIRAVKSLRNVAVDHLRLGELVRTDRLPQYEKFNESGQFFTLEPSYAQSGK
PFTNMGRITGAGSLNGRSDKFYQELEMLFELSLSFPVARQAAPKASSIYYISKHRMMSYY
PWPSDEQRFRDELLKKQQFQLVTPAMNPQRSVAWSPAYVEPNGKGLLTTVGVPIYLEDEF
IGSINLDMTLSSLDKQIRLYFKMPGTVILLDQQNNILSHSDIDAADINRVFHISQKIPSA
LHSVPESELFDAHEGIMRNGYYIHSVALQNAPWRLLYLQDENELFKDSWEKLELTFLLVV
IALSVLVTIVHWQTRRSFVNPASRLLSHLEGCSQEPRKPPAKITQGWEPWFQLVSRIFEE
NQQYTRHLAEQNRRLDNLVARRTERLKETTERREREYALLRSLLDSIPEAIIFKDKEGKY
LGCNKSAERMLGYTESEMIGQDSQTMTSNEQSMRIRAEDERVLSERTPLRYQEKVELAGK
PVLLDTLKLPFYNRRGELLGLIAVWRDVTREYESAEQLRLSEERYHLAMDAVEDGLWDWY
LDSEQIICNPAYYSMLGYKSNEFPALVSTIDELVHPDDRIRVQEYREQYLADPIGAYDVE
FRMRGKSGMYHWVLSRGRVVEFTSDNQPKRMVGTHKDITRHKSNEVALLEAKQDAESANL
YKSEFLANMSHEIRTPMNAIIGMLQLASRTQLTPQQADYLDKAGFSAQSLLRIINDILDF
SKIEAGKLELERVAFPLDKVLDHALDLNALKAQEKGVELLLYAPVTAGLILEGDPLRLGQ
VLINMLSNAVKFTQSGEIELGCEDVGERDHRITLKFWVRDTGIGISKEQQESLFDAFAQA
DGSTTRKYGGTGLGLSISKHLVSMMGGTMQVQSELGVGSTFSFTISFEIAEEAEVKPLIV
PEVIGNLKTLVVDDNPTALQIYSTAMRDFHFDVDTASNGAEALYKLEHRPVDLLLLDWMM
PEMDGVEVIKALDAMVADGRLEKRPVIIMMTAYASEPLKEDLDDLDIYAMLQKPFKASAL
FDEIIAAFIDKPKINPAAALPVEGNATGTGQILLVEDNFINQQVATELLKSAGYEVDVAE
NGQVALDMVDAKQYDAVLMDIQMPVMDGLTATKELRKRYTKEELPVIAMTAHAMSGDREK
SLAAGMNAHITKPIVLNELFDTLAQWIVRH