Protein Info for Shew_0424 in Shewanella loihica PV-4

Annotation: amino acid carrier protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 transmembrane" amino acids 16 to 38 (23 residues), see Phobius details amino acids 70 to 94 (25 residues), see Phobius details amino acids 100 to 121 (22 residues), see Phobius details amino acids 149 to 168 (20 residues), see Phobius details amino acids 187 to 206 (20 residues), see Phobius details amino acids 217 to 240 (24 residues), see Phobius details amino acids 246 to 249 (4 residues), see Phobius details amino acids 251 to 270 (20 residues), see Phobius details amino acids 306 to 332 (27 residues), see Phobius details amino acids 352 to 374 (23 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 420 to 441 (22 residues), see Phobius details TIGR00835: amino acid carrier protein" amino acids 16 to 444 (429 residues), 500.3 bits, see alignment E=2.2e-154 PF01235: Na_Ala_symp" amino acids 58 to 452 (395 residues), 484.6 bits, see alignment E=1.5e-149

Best Hits

Swiss-Prot: 53% identical to Y883_HAEIN: Uncharacterized transporter HI_0883 (HI_0883) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03310, alanine or glycine:cation symporter, AGCS family (inferred from 100% identity to slo:Shew_0424)

Predicted SEED Role

"Sodium:alanine symporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q9Z8 at UniProt or InterPro

Protein Sequence (457 amino acids)

>Shew_0424 amino acid carrier protein (RefSeq) (Shewanella loihica PV-4)
MEGITEFVSTINGFVWGTPMLVMILGVGLFLSFGLRLMPILKLGTGFKLLWSGRIPDKDK
QMKGEISPFNALMTSLSATIGTGNIAGVATAIFIGGPGALFWMWCTALVGMATKFSEAVL
AVKYREVDDNGNHIGGPMYYIKNGLGSKWAWLGTAFALFGSFAGFGIGNTVQANSVADAL
NSNFGVPTWVTGLVLMVLVGAVLMGGIKRIADVAGKLVPLMTVFYIAAGLSVIVVNAAAI
PDAIALIVHSAFNPVAAQGGFAGAAVWAAVRFGVARGVFSNEAGLGSAPIAHAAAQTNNP
VAQGLVAMLGTFIDTLVVCTITGLAIVVSGAWTSGENGAALTSYAFSHALPMGNYIVAIA
LSIFAFTTILGWSVYSEKCVQYLFGVRAVKPFRAIWVIVVPLGAVSSLDFIWLLADTLNA
MMAIPNLIALSLLSPVVFGLTREYFIKKRQQEAEASS