Protein Info for Shew_0367 in Shewanella loihica PV-4

Annotation: cytochrome-c oxidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 662 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 60 to 77 (18 residues), see Phobius details amino acids 106 to 130 (25 residues), see Phobius details amino acids 143 to 165 (23 residues), see Phobius details amino acids 192 to 216 (25 residues), see Phobius details amino acids 236 to 257 (22 residues), see Phobius details amino acids 290 to 308 (19 residues), see Phobius details amino acids 319 to 338 (20 residues), see Phobius details amino acids 349 to 371 (23 residues), see Phobius details amino acids 383 to 406 (24 residues), see Phobius details amino acids 419 to 443 (25 residues), see Phobius details amino acids 458 to 477 (20 residues), see Phobius details amino acids 496 to 521 (26 residues), see Phobius details amino acids 597 to 629 (33 residues), see Phobius details TIGR02843: cytochrome o ubiquinol oxidase, subunit I" amino acids 5 to 650 (646 residues), 1126.5 bits, see alignment E=0 PF00115: COX1" amino acids 59 to 507 (449 residues), 483.3 bits, see alignment E=3.6e-149

Best Hits

Swiss-Prot: 72% identical to CYOB_PSEAE: Cytochrome bo(3) ubiquinol oxidase subunit 1 (cyoB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02298, cytochrome o ubiquinol oxidase subunit I [EC: 1.10.3.-] (inferred from 100% identity to slo:Shew_0367)

MetaCyc: 71% identical to cytochrome bo terminal oxidase subunit I (Pseudomonas putida KT2440)
RXN0-5268 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit I (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q9U1 at UniProt or InterPro

Protein Sequence (662 amino acids)

>Shew_0367 cytochrome-c oxidase (RefSeq) (Shewanella loihica PV-4)
MSSFLGKLTLDAVPFHEPIIMVTLAAVAVIGLVIAALITKHKKWGPLWRDWLTSVDHKRL
GIMYILLAFVMLIRGFSDAIMMRTQQAMATNGAAGYLPPEHYDQIFTAHGVIMIIFMAMP
FMIGLMNLVLPLQIGARDVAFPFLNNLSFWLTASGAVLINISLGVGEFAKTGWVAYPPLS
ELAYSPGVGVDYYIWALQISGIGTTLTGVNFLVTVLKMRAPGMKLMQMPIFTWTCTWANI
LIVASFPILTAVLAMLTLDRYMDFHFFTNEGGGNAMMYINLFWAWGHPEVYILILPAFGI
FSEVISTFTAKRLFGYKSMVWASGAISILGFIVWLHHFFTMGSSANVNAFFGVMTMVIAV
PTGVKLFNWLFTIYRGRLKLTVPVLWTLGFMVTFTIGGMTGVLLAVPGADYVLHNSLFLI
AHFHNTIIGGAVFGYLAGFAFWFPKATGFHLNERLGKAAFWCWQAGFYVAFMPLYVLGFL
GMTRRLNQTDNPDWNFWIYLAAVGACIIFVGIVLQFVQLYVSIRDREQNRDTTGDPWNGH
TLEWSTASPPQFYNFARLPKVVDIDAFTHAKEQGQAYQMQESYQPIHMPKNTGHGVWMAL
GITAAGFAAIWHILWLAIAGFLGAFIVFLMRAYDTDTDYYVQGDEVKRIETAHLNNLSKG
QI