Protein Info for Shew_0070 in Shewanella loihica PV-4
Annotation: iron-containing alcohol dehydrogenase (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 100% identity to slo:Shew_0070)Predicted SEED Role
"NADH-dependent butanol dehydrogenase A (EC 1.1.1.-)" in subsystem Butanol Biosynthesis (EC 1.1.1.-)
MetaCyc Pathways
- 1-butanol autotrophic biosynthesis (engineered) (21/27 steps found)
- pyruvate fermentation to butanol II (engineered) (5/6 steps found)
- glycerol degradation to butanol (10/16 steps found)
- butanol and isobutanol biosynthesis (engineered) (4/8 steps found)
- pyruvate fermentation to butanol I (4/8 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Ethylbenzene degradation
- Fructose and mannose metabolism
- Glycine, serine and threonine metabolism
- Insect hormone biosynthesis
- Limonene and pinene degradation
- Linoleic acid metabolism
- Naphthalene and anthracene degradation
- Nucleotide sugars metabolism
- Polyketide sugar unit biosynthesis
- Retinol metabolism
- Tetrachloroethene degradation
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-
Use Curated BLAST to search for 1.1.-.- or 1.1.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A3Q8Z5 at UniProt or InterPro
Protein Sequence (387 amino acids)
>Shew_0070 iron-containing alcohol dehydrogenase (RefSeq) (Shewanella loihica PV-4) MLNFDYRNPTQIVFGKDRLAELDKLIPAGARVMVTYGGGSVKRFGTLDKVLSALGDRTVV EFGGIEANPQYETLAKAAKLAREESIDFLLAVGGGSVMDGTKFIALATRFEGDSDSLLFH GFAPVPVEADQVLPLGTIATLPATGSEMNAFGVVSYNGGKFPVNHPSIYPTFSLLDPTLT FTLPKIQVANGVVDAFVHVLEQYATYPVDGRVQDRTAEGIMRTLIEIGPITLEEPENYNA RANLMWSATSALNGMIGAGVPFDWTTHMIGHELTAQFGIDHAQTLAAVLPSVWRVRKIQK HAKLLQYAERVWDITEGDEASRVDLAIDKTEQFFQQLGLKTHLRDYDIAQEQIDDIVAAL EAHGMTALSESGDLGLDISREILQLAW