Protein Info for Shew_0059 in Shewanella loihica PV-4

Annotation: molybdopterin oxidoreductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 949 transmembrane" amino acids 25 to 46 (22 residues), see Phobius details PF04879: Molybdop_Fe4S4" amino acids 62 to 112 (51 residues), 45.9 bits, see alignment 6.8e-16 PF00384: Molybdopterin" amino acids 118 to 568 (451 residues), 162.2 bits, see alignment E=2.7e-51 PF01568: Molydop_binding" amino acids 815 to 940 (126 residues), 80 bits, see alignment E=2e-26

Best Hits

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 79% identity to fbl:Fbal_3582)

Predicted SEED Role

"Formate dehydrogenase-O, major subunit (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.2

Use Curated BLAST to search for 1.2.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q8Y4 at UniProt or InterPro

Protein Sequence (949 amino acids)

>Shew_0059 molybdopterin oxidoreductase (RefSeq) (Shewanella loihica PV-4)
MRLTRKTDQAEVAKKPALGLSRRQFLQSAGLATGGIAAASMLGAGMMRKAEAKEVPHDAP
TEVKRTICSHCSVGCGIYAEVQNGVWTGQEPAFDHPFNAGGHCAKGASLREHGHGEKRLK
YPMKLEGGKWKRISWDQAIEEVGQKALDIRKESGPDSIFFMGSAKFSNEQAYLYRKFAAM
WGTNNVDHSARICHSTTVAGVANTWGYGAQTNSFNDIRNAKAMMFIGSNPSEAHPVAMQH
ILEGKERGAKIIVVDPRFTRTAAKADEYVHIRPGTDIPYIYGLLWHIFENKWEDQTFIDQ
RVYGMERIREAAAKWNPEEVENVVGVPKEQMYRVAKTLAETKPGTIVWCMGGTQHHIGNA
NTRAYCILQLALGNMGVSGGGTNIFRGHDNVQGATDFGLLFDTLPGYYGLKTGSWKHWCN
VWDLDYEWVKARFDQEQRLGQDPMTSTGIPCSRWHDGVLEDKSKIAQKDNIRMSFFWGQS
VNTETRGREVREALNKMDTVVVVDPFPTMAGVMHTRKDGVYLLPAATQFETYGSVSASNR
SLQWRSQVIEPLFESKPDHVIMYKLAKKWGIEKELCKHIQVNGDEPLIEDIVREYNKGMW
TIGYTGQSPERLKMHQENWGTFDIKSLEAPGGPAKGETYGLPWPCWGTPEMKHPGTQILY
RTDREVRFGGGNFRARYGVEHDGNNILAEGSYSKGSEIKDGYPEFTDKMLKQLGWWDDLT
AEEKAAAEGKNWKTDISGGIQRVAIKHGCIPFGNAKARCIVWNFPDDIPVHREPLYTPRR
DLVSKYPTYDDRMVARLPTLYKSIQDQDFAKEFPLALTSGRLVEYEGGGEETRSNPWLAE
LQQEMFIEINPADAADRGLRDGDVVWVHSPEGAKIKVQAMVTPRVIEGECFMPYHFAGMF
EGESLEKSYPEGTVPYIIGESANTVLTYGYDVVTQMQETKSSLCQITKA