Protein Info for Shew_0022 in Shewanella loihica PV-4

Annotation: TrkH family potassium uptake protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 38 to 57 (20 residues), see Phobius details amino acids 69 to 90 (22 residues), see Phobius details amino acids 106 to 120 (15 residues), see Phobius details amino acids 133 to 160 (28 residues), see Phobius details amino acids 184 to 203 (20 residues), see Phobius details amino acids 210 to 224 (15 residues), see Phobius details amino acids 237 to 258 (22 residues), see Phobius details amino acids 278 to 297 (20 residues), see Phobius details amino acids 333 to 356 (24 residues), see Phobius details amino acids 398 to 420 (23 residues), see Phobius details amino acids 458 to 480 (23 residues), see Phobius details PF02386: TrkH" amino acids 37 to 479 (443 residues), 326.4 bits, see alignment E=1.4e-101 TIGR00933: potassium uptake protein, TrkH family" amino acids 84 to 468 (385 residues), 390.5 bits, see alignment E=4.5e-121

Best Hits

Swiss-Prot: 70% identical to TRKH_VIBPA: Trk system potassium uptake protein TrkH (trkH) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K03498, trk system potassium uptake protein TrkH (inferred from 100% identity to slo:Shew_0022)

MetaCyc: 64% identical to K+ transporter TrkH (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Potassium uptake protein TrkH" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A3Q8U7 at UniProt or InterPro

Protein Sequence (485 amino acids)

>Shew_0022 TrkH family potassium uptake protein (RefSeq) (Shewanella loihica PV-4)
MQYRTIIRITGLLMGLFSLSLLPPALVAVIYKDGGGTAFLQAFFLSLLLGFVLWYPNRRH
KKDLRTREGFMLVVLFWGVLGSIGAVPFIFSSQPDLSLTDSFFESFSALTTTGATVLVGL
DSLPKAILFYRHLLQWLGGMGIIVLAVAILPVLGIGGMQLYRAEIPGPVKDSKMTPRIAE
TAKALWYIYLALTIACAFAYWVAGMDVFDAICHSFSTIAIGGFSTHDASMGYFDSTAINM
VCVVFLLIAALNFSLHFAAFTRRGINLKVYLRDAEFKALIVIQLALTLICFATLYHTGIY
DSAEETFDFALFQAVSISTTAGFGTESFHMWPLFLPMLLIFSSFIGGCGGSTAGGIKVMR
MILLLLQGSRELKRLVHPRGMFSIRINGKALPDRIIDAVWGFFSAYALVFVVCMLILMAL
GMDNITAFSATAACLNNLGPGLGEVASNYASIGDGEKWVLVVAMLFGRLEVFTLLVLFTP
TFWKN