Protein Info for Dshi_3317 in Dinoroseobacter shibae DFL-12

Annotation: phosphoserine aminotransferase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 63% identical to SERC_METBF: Phosphoserine aminotransferase (serC) from Methanosarcina barkeri (strain Fusaro / DSM 804)

KEGG orthology group: K00831, phosphoserine aminotransferase [EC: 2.6.1.52] (inferred from 100% identity to dsh:Dshi_3317)

MetaCyc: 63% identical to phosphoserine aminotransferase monomer (Methanosarcina acetivorans)
Phosphoserine transaminase. [EC: 2.6.1.52]; Aspartate transaminase. [EC: 2.6.1.52, 2.6.1.1]

Predicted SEED Role

"Phosphoserine aminotransferase (EC 2.6.1.52)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 2.6.1.52)

MetaCyc Pathways

superpathway of aromatic amino acid biosynthesis (18/18 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
superpathway of L-isoleucine biosynthesis I (13/13 steps found)
superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
aspartate superpathway (21/25 steps found)
superpathway of L-phenylalanine biosynthesis (10/10 steps found)
superpathway of L-tyrosine biosynthesis (10/10 steps found)
superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
TCA cycle VIII (Chlamydia) (6/6 steps found)
superpathway of L-threonine biosynthesis (6/6 steps found)
superpathway of L-methionine biosynthesis (transsulfuration) (8/9 steps found)
superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
pyridoxal 5'-phosphate biosynthesis I (6/7 steps found)
L-phenylalanine biosynthesis I (3/3 steps found)
L-serine biosynthesis I (3/3 steps found)
L-tyrosine biosynthesis I (3/3 steps found)
malate/L-aspartate shuttle pathway (2/2 steps found)
L-tyrosine degradation I (4/5 steps found)
3-(4-hydroxyphenyl)pyruvate biosynthesis (1/1 steps found)
L-aspartate biosynthesis (1/1 steps found)
L-aspartate degradation I (1/1 steps found)
(R)-cysteate degradation (2/3 steps found)
L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
sulfolactate degradation III (2/3 steps found)
superpathway of sulfolactate degradation (4/6 steps found)
L-glutamate degradation II (1/2 steps found)
L-tryptophan degradation IV (via indole-3-lactate) (1/2 steps found)
L-tyrosine degradation II (1/2 steps found)
atromentin biosynthesis (1/2 steps found)
L-phenylalanine degradation III (2/4 steps found)
L-tyrosine degradation III (2/4 steps found)
anaerobic energy metabolism (invertebrates, cytosol) (4/7 steps found)
L-asparagine degradation III (mammalian) (1/3 steps found)
L-phenylalanine degradation II (anaerobic) (1/3 steps found)
L-tyrosine degradation IV (to 4-methylphenol) (1/3 steps found)
indole-3-acetate biosynthesis VI (bacteria) (1/3 steps found)
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (7/12 steps found)
L-tryptophan degradation VIII (to tryptophol) (1/4 steps found)
superpathway of L-aspartate and L-asparagine biosynthesis (1/4 steps found)
superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
4-hydroxybenzoate biosynthesis I (eukaryotes) (1/5 steps found)
L-phenylalanine degradation VI (reductive Stickland reaction) (1/5 steps found)
L-tryptophan degradation XIII (reductive Stickland reaction) (1/5 steps found)
L-tyrosine degradation V (reductive Stickland reaction) (1/5 steps found)
superpathway of plastoquinol biosynthesis (1/5 steps found)
C4 photosynthetic carbon assimilation cycle, NAD-ME type (5/11 steps found)
C4 photosynthetic carbon assimilation cycle, PEPCK type (7/14 steps found)
coenzyme M biosynthesis II (1/6 steps found)
superpathway of chorismate metabolism (38/59 steps found)
L-phenylalanine degradation IV (mammalian, via side chain) (2/9 steps found)
indole-3-acetate biosynthesis II (4/12 steps found)
rosmarinic acid biosynthesis I (2/10 steps found)
(S)-reticuline biosynthesis I (1/11 steps found)
superpathway of rosmarinic acid biosynthesis (2/14 steps found)
anaerobic aromatic compound degradation (Thauera aromatica) (2/27 steps found)
Methanobacterium thermoautotrophicum biosynthetic metabolism (19/56 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.1

Use Curated BLAST to search for 2.6.1.1 or 2.6.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LNF6 at UniProt or InterPro

Protein Sequence (384 amino acids)

>Dshi_3317 phosphoserine aminotransferase (RefSeq) (Dinoroseobacter shibae DFL-12)
MALDAPVTRPANPRFSSGPCAKPPTWTLDTLGDAALGRSHRATVGKDKLKAAIETTREVL
GVPADYKIGIVPASDTGAYEMAMWSLLGERPVEMLAWESFGSGWVTDAIKQLKLDATTRT
AEYGEIVDLAAVDFDKDVCFTWNGTTSGVRVPDGDWIPADRAGLTLCDATSAAFAMDLAW
DKLDATTFSWQKVLGGEAAHGILILSPRAVARLESYTPPWPLPKIFRLTKGGKLIDGIFR
GETINTPSMLCVEDYLFALDWAKSVGGLPGLIARAEANTAAIAAFVAANDWIDFLAADPA
TRSTTSVCLKFTDDRIADGAAFAKAVAKRLEAEGIAFDIGAYRDAPPGLRIWCGGTVETS
DVEALLPWLSWAFEAEIAAQLAEA