Protein Info for Dshi_3234 in Dinoroseobacter shibae DFL-12

Annotation: Leucyl aminopeptidase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 transmembrane" amino acids 255 to 275 (21 residues), see Phobius details PF21337: Peptidase_M17_N_1" amino acids 17 to 135 (119 residues), 53.1 bits, see alignment E=3.4e-18 PF00883: Peptidase_M17" amino acids 153 to 453 (301 residues), 326.1 bits, see alignment E=2.4e-101

Best Hits

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 100% identity to dsh:Dshi_3234)

Predicted SEED Role

"Peptidase B (EC 3.4.11.23)" (EC 3.4.11.23)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.1

Use Curated BLAST to search for 3.4.11.1 or 3.4.11.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LMP2 at UniProt or InterPro

Protein Sequence (463 amino acids)

>Dshi_3234 Leucyl aminopeptidase (RefSeq) (Dinoroseobacter shibae DFL-12)
MSDPLYSFAPPGVPARPIHVVPEGETDTALASLSGPQRRWAEAQGFTGKLGSHVILPDPE
GAPVAVLAGYGTAESRARQRFALAPLATALPAGDYAFHGLDDPAALAEQSLGWLLAGYGF
TRYKGTPATPARLQLAPGLDAARLIACAAGEALTRDLINTPANDMGPEELEAAARSLASR
FAADITVIRDQDLLAQNFPLIHTVGHASDRRPRLIDLRWGDAGPALTLVGKGVCFDTGGL
NLKPGVSMALMKKDMGGAATVLGLAQMIMALGLRLRLRVLIPAVENSVAGGAFRPGDILP
SRKGLTVEINNTDAEGRLVLADALALADEESPDLILSMATLTGAARVAVGPDLAPFYATR
PEDAAALRAGAVRAADPVWEMPFHAPYEKMIEPGIADLDNAPSGGFAGSITAALFLRRFV
EAPRYLHFDIYGWQPSAAPARPKGGAGQGARAVLEALPELLGL