Protein Info for Dshi_2776 in Dinoroseobacter shibae DFL-12

Annotation: Alcohol dehydrogenase zinc-binding domain protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 PF08240: ADH_N" amino acids 25 to 85 (61 residues), 39.6 bits, see alignment E=6.3e-14 PF00107: ADH_zinc_N" amino acids 149 to 265 (117 residues), 100.5 bits, see alignment E=1.1e-32 PF13602: ADH_zinc_N_2" amino acids 182 to 317 (136 residues), 82 bits, see alignment E=1.3e-26

Best Hits

Swiss-Prot: 37% identical to QORL2_NEMVE: Quinone oxidoreductase-like protein 2 homolog (v1g238856) from Nematostella vectensis

KEGG orthology group: K00344, NADPH2:quinone reductase [EC: 1.6.5.5] (inferred from 100% identity to dsh:Dshi_2776)

Predicted SEED Role

"Oxidoreductase, zinc-binding dehydrogenase family"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.6.5.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LJ14 at UniProt or InterPro

Protein Sequence (319 amino acids)

>Dshi_2776 Alcohol dehydrogenase zinc-binding domain protein (RefSeq) (Dinoroseobacter shibae DFL-12)
MRAFRTHAHDAPPALEDIPVPDPGPGELRLRIAACGLNFADLLMARGQYQEQPPLPLTLG
MEVAGTVDALGPDTTGPAPGTRVAVFGGQGGLAKYGVFPAARCVPLPDGMPETEAAGFQI
AYGTSHLALSHTARLQPGETLLVLGAAGGVGLTAVEIGKLMGATVIASARGPAKLDQARK
AGADHLVDSDTDDLREAVKSLGGADVVYDPVGGAAFTEALRACKPEARMLLIGFASGDLP
EIKPNHLLVKNVSVQGFYWGGFLNFNPTALTDSLAQLFDWYAQGRIKPHVSHVLPLEKAA
DGLDLLRSRRSTGKVVITP