Protein Info for Dshi_2126 in Dinoroseobacter shibae DFL-12

Annotation: peptidase M24 (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01321: Creatinase_N
  • amino acids 34 to 164 (131 residues), 50.3 bits, E=3.6e-17
• PF00557: Peptidase_M24
  • amino acids 172 to 388 (217 residues), 95.7 bits, E=3.4e-31

Best Hits

Swiss-Prot: 65% identical to CREA_BACB0: Creatinase from Bacillus sp. (strain B-0618)

KEGG orthology group: K08688, creatinase [EC: 3.5.3.3] (inferred from 100% identity to dsh:Dshi_2126)

MetaCyc: 64% identical to creatinase (Arthrobacter sp. TE1826)
Creatinase. [EC: 3.5.3.3]

Predicted SEED Role

"Creatinase (EC 3.5.3.3)" (EC 3.5.3.3)

MetaCyc Pathways

• creatinine degradation I (3/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.3

Sequence Analysis Tools

See A8LQJ5 at UniProt or InterPro

Protein Sequence (410 amino acids)

>Dshi_2126 peptidase M24 (RefSeq) (Dinoroseobacter shibae DFL-12)
MDGNTNVDDMLHVMEWHNGEKEFSPFSDTEMARRQNELRDWMAKNDVDASLFTSYHCINY
YSGWLYCYFGRKYGMVIDQKNATTISAGIDGGQPFRRSFGNNITYTDWRRDNFYRAIQQL
TPGAKRIGIEFDHVSLEYRQLLQDALPGVEFVDVGQPAMWMRTIKSAEEIKLIKEGARVA
DVGGAAVAAAVKAGVPEHEVAIAGTTAMIREIANSFPFVELMDTWTWFQSGINTDGAHNP
VTNKKVQSGEILSLNTFPMIFGYYTALERTLFCDHVDDASLDIWEKNVKVHERGLQLIKP
GARCMDIAIELNEMYREWDLLKYRSFGYGHSFGVLSHYYGREAGVELREDIETELKPGMV
VSMEPMVMIPEGQPGAGGYREHDILVINDDNTVENITGFPFGPEHNIIKN