Protein Info for Dshi_2042 in Dinoroseobacter shibae DFL-12

Annotation: aminotransferase class-III (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 75% identical to HTPA_PARDP: Hypotaurine/taurine--pyruvate aminotransferase (hpa/tpa) from Paracoccus denitrificans (strain Pd 1222)

KEGG orthology group: K03851, taurine-pyruvate aminotransferase [EC: 2.6.1.77] (inferred from 100% identity to dsh:Dshi_2042)

MetaCyc: 75% identical to hypotaurine--pyruvate aminotransferase (Paracoccus denitrificans PD1222)
Taurine--pyruvate aminotransferase. [EC: 2.6.1.77]; 2.6.1.77 [EC: 2.6.1.77]

Predicted SEED Role

"Taurine--pyruvate aminotransferase (EC 2.6.1.77)" (EC 2.6.1.77)

MetaCyc Pathways

hypotaurine degradation (3/3 steps found)
taurine degradation I (1/1 steps found)
superpathway of taurine degradation (3/6 steps found)

KEGG Metabolic Maps

Taurine and hypotaurine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.77

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LPS6 at UniProt or InterPro

Protein Sequence (460 amino acids)

>Dshi_2042 aminotransferase class-III (RefSeq) (Dinoroseobacter shibae DFL-12)
MTTHVAPNDLSHVIEADRAHQWHHLINHKPFETTDPRIIVEGKGMRVWDALGKEHLDAVS
GGLWTVNVGYGRERIANAVRDQLMQMCFFSNSLGTIPGAIFSEMLIDKMPGMSRVYYASS
GSEANEKAFKMVRQIAHKVHGGRKTKILYRERDYHGSTLATMSAGGQWERKAQYGPFAPD
FVEVPHCLEYRAQWEGENYGERAADAIEEVILREGPDTVGALCLEPVTAGGGVITPPEGY
WPRVQEICRKYDVLLHIDEVVCGLGRTGKWFGYQHYGIEPDFVTMAKGVASGYAAISCMV
TTERVFEMFKSEPGAPLDYFRDISTFGGCTAGPAAAIENMKIIEEEDLLGNTDRMHDQLM
GNLAGLMEKHRVIGDIRGKGLFCGAELVADRTTKEPAPEALVQAVVADCMAQGVIIGATN
RSLPGYNNTLCFSPALIATADDIDQITDAVDGALTRVFGA