Protein Info for Dshi_1127 in Dinoroseobacter shibae DFL-12

Annotation: response regulator receiver protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 PF13614: AAA_31" amino acids 182 to 342 (161 residues), 42.2 bits, see alignment E=1.4e-14 PF10609: ParA" amino acids 183 to 423 (241 residues), 32.2 bits, see alignment E=1.2e-11

Best Hits

KEGG orthology group: K02282, pilus assembly protein CpaE (inferred from 100% identity to dsh:Dshi_1127)

Predicted SEED Role

"Type II/IV secretion system ATPase TadZ/CpaE, associated with Flp pilus assembly" in subsystem Widespread colonization island

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LHS2 at UniProt or InterPro

Protein Sequence (435 amino acids)

>Dshi_1127 response regulator receiver protein (RefSeq) (Dinoroseobacter shibae DFL-12)
MTAVAPLSGKNTDETQGVEIPTDEAPILACTVSRDVQNFEILIDEMEARFQDAWGDLRIS
EALDFLDQPDAARVQVLALALDLEDESNVDTVLDIVRKATELSISVLLIADELDPIVLHQ
VLQAGAREFLPYPIPEQGLTEAVERLSRAARPPIPLADAVNVAEIPATEATLPTRTAGGC
TIFAVQGLAGGVGATTFAVNLAWELATLKGTTPRVGLMDMDQQFGSVATYLDLPRKDLIF
ELMSDVDSLDDDAFRQALQIVDGKLSVFTSPAEILPLDLLPPEDMDKLISTAAGMFDYLV
IDMPSALVNWTETALRMADVFFPVIELDLRSAQNALRFVKTLKFEDLPVEKLRFVLNRAP
KMTDLAGKARVKRMAESLDISFGEKLPDGGKAVAESNDHGSPLALRARKNPLRKEIAKLA
QSLHDVSTGAEAANG