Protein Info for Dshi_1115 in Dinoroseobacter shibae DFL-12

Annotation: ATP-dependent metalloprotease FtsH (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 101 to 121 (21 residues), see Phobius details PF06480: FtsH_ext" amino acids 8 to 91 (84 residues), 49.2 bits, see alignment E=1.4e-16 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 103 to 593 (491 residues), 760.6 bits, see alignment E=3.7e-233 PF07728: AAA_5" amino acids 191 to 276 (86 residues), 22.1 bits, see alignment E=3.2e-08 PF00004: AAA" amino acids 191 to 322 (132 residues), 162.4 bits, see alignment E=1.9e-51 PF17862: AAA_lid_3" amino acids 345 to 388 (44 residues), 51.2 bits, see alignment 1.8e-17 PF01434: Peptidase_M41" amino acids 403 to 592 (190 residues), 227.3 bits, see alignment E=3.7e-71

Best Hits

Swiss-Prot: 62% identical to FTSH_BARBK: ATP-dependent zinc metalloprotease FtsH (ftsH) from Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to dsh:Dshi_1115)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LHR0 at UniProt or InterPro

Protein Sequence (638 amino acids)

>Dshi_1115 ATP-dependent metalloprotease FtsH (RefSeq) (Dinoroseobacter shibae DFL-12)
MGNLRNVAFWVVLFLLILALFNLFSGGQSTVNSRAITYSEFVDRVEQGDVASVVLDGENV
TMRTGDGQQLTTVKPEGVDVTGLLLEENVQIEARAQEQSGILSYIGTLLPFLILIGIWIF
FMNRMQGGGRGGAMGFGKSKAKLLTEKQGRVTFDDVAGIDEAKDDLEEIVEFLRNPQKFS
RLGGKIPKGALLVGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDMFE
QAKKNAPCIVFIDEIDAVGRSRGVGYGGGNDEREQTLNQLLVEMDGFEANEGIIIVAATN
RPDVLDPALLRPGRFDRQVQVPNPDIKGREKILGVHARKVPLGPDVDLRIIARGTPGFSG
ADLANLVNESALMAARVGRRFVTMEDFESAKDKVMMGAERRSMVMTEEEKALTAYHEAGH
AIVGLNVPQHDPIHKATIIPRGRALGLVMSLPERDQLSVTKTKYISKIAMAMGGKVAEEL
KFGPENVTSGATSDIQQVSKIARAMVTQFGFAEELGHVDYANEQQSYLGSYGGGTNHSQE
TQKIIDQKVKEIIDEGYNTAKRILTEKKDEWERLAQGLLEYETLTGAEIQKVINGEPLNR
GDDEDDTPTSGTPSVTAIPKAKSRSKPRDGGMEPEPST