Protein Info for Dshi_0204 in Dinoroseobacter shibae DFL-12

Annotation: acyl-CoA dehydrogenase domain protein (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 564 PF02771: Acyl-CoA_dh_N" amino acids 181 to 292 (112 residues), 116.4 bits, see alignment E=1.8e-37 PF02770: Acyl-CoA_dh_M" amino acids 298 to 400 (103 residues), 70.3 bits, see alignment E=2.6e-23 PF00441: Acyl-CoA_dh_1" amino acids 414 to 563 (150 residues), 139.6 bits, see alignment E=1.9e-44 PF08028: Acyl-CoA_dh_2" amino acids 431 to 550 (120 residues), 48.5 bits, see alignment E=2.2e-16

Best Hits

KEGG orthology group: K14448, (2S)-methylsuccinyl-CoA dehydrogenase (inferred from 100% identity to dsh:Dshi_0204)

Predicted SEED Role

"Methylsuccinyl-CoA dehydrogenase, predicted by (Erb et al, 2007)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A8LLE3 at UniProt or InterPro

Protein Sequence (564 amino acids)

>Dshi_0204 acyl-CoA dehydrogenase domain protein (RefSeq) (Dinoroseobacter shibae DFL-12)
MPHDGQDLSLNDAQTVVLPDLLNLTAAAVPPVEAVLEKAVAILKTQLAVDGRISGALVEE
HQTASHGLAWLATYAQSLRQMQKWAETLQADGKFGEVEQLIHQIAFGEYLWQLYGGIPMS
QGEILRLQDIGLSQDDQRGLMTPEIQTLTRSGNTQAARTRLVELMQERAAEITVGATGLD
DELEMIREQFRRFSVDKVEPHAHEWHLKDELIPMEIIEELAEMGVFGLTIPEEYGGFGLS
KASMCVVSEELSRGYIGVGSLGTRSEIAAELIICGGTEEQKQKWLPRLASAETLPTAVFT
EPNTGSDLGALRTRAVQDENGDWKVTGNKTWITHAARTHVMTLLARTKPDTTDHRGLSMF
LAEKTPGTDEAPFPTEGMTGGEIEVLGYRGMKEYELAFDNFHVKGENLLGGEEGKGFKQL
METFESARIQTAARAIGVAQSALDVSMQYAIDRKQFGKSLINFPRVSGKLAMMAVEIMVA
RQLTYFSAFEKDEGRRCDVEAGMAKLLGARVAWAAADNGLQIHGGNGFALEYGISRILCD
ARILNIFEGAAEIQAQVIARRLLG