Protein Info for BT4337 in Bacteroides thetaiotaomicron VPI-5482

Annotation: beta-hexosaminidase precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 844 signal peptide" amino acids 1 to 15 (15 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 64 to 196 (133 residues), 93.1 bits, see alignment E=4.6e-30 PF00728: Glyco_hydro_20" amino acids 199 to 559 (361 residues), 414.8 bits, see alignment E=7.3e-128 PF13290: CHB_HEX_C_1" amino acids 606 to 661 (56 residues), 48.8 bits, see alignment 1.1e-16 PF13287: Fn3_assoc" amino acids 608 to 664 (57 residues), 66.7 bits, see alignment 3e-22

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to bth:BT_4337)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89ZN9 at UniProt or InterPro

Protein Sequence (844 amino acids)

>BT4337 beta-hexosaminidase precursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MFVTSAFLFLYCWNLPIKQVHLSCQYINNLTQFQTMKKSISLLLLSLLMITPSCQKPKEV
TNEYNIVPQPNQLVPKEGRFELSNKVRLVVPSDAPEVKKVADGFAEQLKQTAGISLTEAE
SVDGKPAISFVLQEGMPKEGYKLSVTPTLITVTASQPNGFFYGVQTIYQLLPPAVYGKEL
KKKADWSVPAVEIEDAPRFVHRGLMLDVCRHYAPIEYIYKFIDLLAMNKMNVFHWHLTDD
QGWRIEIKKYPKLTEIGSKREKTLVDYYYVNYPQVFDGIEHGGYYTQEQIKEVVAYAASK
YINVIPEIEMPGHALAALAAYPELSCDSTQTYKVSPTWGVFEQVFCPSETTFKFFEGVMD
EVVELFPSEYIHIGGDECPKTAWKNSTFCQQLIRQLGLKDDATPSKVDGVKHSKEDKLQS
YFVTRMEKYLNGKGRNIIGWDEILEGGLAPNATVLSWRGVEGGLNAAKAGHNAIMAPMPY
AYLDFYQEDPEIAPTTIGGYTTLKKTYSYNPVPDNADELVKKHIIGMQGNLWREYMKTSD
RVDYQAFPRAMAIAETGWTLDANKNWKSFCERMVTEFERLEVMDTKPCLNFFDVNINTHA
DENGPLMVLLETFYPNAEIRYTTDGSEPTYGSTLYEQPFVLEGNIDLKAAAFKDGKMLGK
VTNKPLYGNLLAGKPFTVNYTMGWTGDIFGDNDVLGADKTTFGLTNGKRGNNASYTPWSS
FAIVEGKDLEFIVHLDKPTEVRKVVFGSLFNPAMRMLPAGGVAVEVSADGQQYTQIAEKA
LKHDCPETGRIAFTDSIEFEPTQATFLKVKIKNGGTLRNGVNFKKNNGPEVIPAELWIDE
IEAY