Protein Info for BT4236 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1385 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 780 to 801 (22 residues), see Phobius details amino acids 842 to 861 (20 residues), see Phobius details PF07494: Reg_prop" amino acids 453 to 471 (19 residues), 15.2 bits, see alignment (E = 6.1e-06) amino acids 494 to 511 (18 residues), 18.4 bits, see alignment (E = 5.4e-07) PF02518: HATPase_c" amino acids 950 to 1059 (110 residues), 53.5 bits, see alignment E=9.2e-18 PF00072: Response_reg" amino acids 1132 to 1242 (111 residues), 84.9 bits, see alignment E=1.4e-27 PF12833: HTH_18" amino acids 1308 to 1384 (77 residues), 64.1 bits, see alignment 3.8e-21

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4236)

Predicted SEED Role

"two-component system sensor histidine kinase/response regulator, hybrid ('one-component system')"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q89ZY5 at UniProt or InterPro

Protein Sequence (1385 amino acids)

>BT4236 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRKFFFLLLLLTVFLPSYSIDTHWDLEPQIIKNGVGNNTIYHVCYGSEGFMWFSTDKGIS
RYDGFRFRDYPLIMSVDSLSTPLHQAVKTLKEGSDGLFYASLYQGGITCFDKEMEKFLPV
RFDRSLKLKEIQDFCWNDGSLYLATSHGLFESRPIRKKEGKEDFVYCILNPEPLIKGKIT
NLCTDGKTNLYFAVDREKVIHYDLVTKRTSVIREYDVVNRLFLRQGYLWICRLWNDIVCY
DLKSHKERVVSLEGGDQPDFSNSYVTDMVMKDKQTFYLTTWDGLYKLHFENLNLCESPFT
LTLLTQGERAFHSRIENKMTSLLWDNRQQILWVGTFGGGVVKFDISDSMYSRVRQNFKSR
VDGMVEDAKGYIWLTVTDGGIMRSTTPSFSMDTHFEPWKKVSGLSGRYHIYKGKDGNIWL
GNNFGEIISVNPLTEDVESFQLKNSEGGRMQAVVHCFCLDSWNRLWVGTSNGLVQVDPKT
HGCKNIKLPGEIKNVFAITEDKEGNVWVGTDKGLKRIETNGDQIRVEGNYEKENGLEEAG
VRTLYVNNYNQIYAAYLNVVIRIDGREKDKIESVYTLQSGLTDGHVSCMVDDHIGNTWAG
NNVGVMTIRNGQEAFYSYLSVGNCSAVCRLNDGRLLWANSWGLIFFDPSATKGDSGKKHL
MLTDVEVGGETVLAGEKRNGQMILAVSPEKQEKLVFASDNNDFHLFFSDLRYGLAQRKIA
YRLLPADKEWKMIPLAEGLWFNGLAAGKYALQAKLVFPDGKEGEVIEIPLVVKGKWYQTI
WAYIMYVLLLGGLSYFFYSYFRKKDQRKQIHRDREMILKENLNLEKLKQEQKKEIEAMRN
RLLMLFVQELRTPLSLIIAPLKELQKDDAQTSQLSLQVAYRNSLRMVDACDQLLAVYGQG
NMESKLEVAPYSVDKMIDSSLFGVRDLLKVYTIDFHCEKRIKKEMEFYVDKKKIEFVIHN
LLTNAFTHTHYAGTVSLSVCEVVNDNMHYVCLIVEDDGKERVRTVEQLMSENEGSERDMS
AAQMGFTIMQQMIEAHYGTITLESTEGKGTKVTVNLPADRDVFENNPNIQFIDPEELTEV
AELEPESAETQKQDLAVEDAVVQQDQQLPLFAEALPAEEVASPVAGGVKKTILIVEDHKD
IRLYLKVLFGNEYNLLMATNGQEGVDTAMKEMPDLIICDVMMPVKDGFECCREVKENPET
CSIPFIMLTAKVEDDDIIHGLQLGADDYVLKPFTPGILKAKVSSLINGRQTLKQMYTKLF
KLPGTDTIVVSEPEQAGEEVKTEDPFITAVIKIVEENICEADFSVKKLAAEMNMSQPTLY
RKVKQSTDYTIIELIRGVRMRRAGVLLKTKQYAVQEVAEMVGYNDIPTFRKHFVDAFGTT
PSTYE