Protein Info for BT4138 in Bacteroides thetaiotaomicron VPI-5482
Annotation: putative aminotransferase (NCBI ptt file)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K14155, cystathione beta-lyase [EC: 4.4.1.8] (inferred from 100% identity to bth:BT_4138)MetaCyc: 37% identical to cysteine-S-conjugate beta-lyase (Streptococcus anginosus)
Cysteine-S-conjugate beta-lyase. [EC: 4.4.1.13]
Predicted SEED Role
"Cystathionine beta-lyase, Bsu PatB (EC 4.4.1.8)" (EC 4.4.1.8)
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
- aspartate superpathway (19/25 steps found)
- L-serine degradation (3/3 steps found)
- L-tryptophan degradation II (via pyruvate) (3/3 steps found)
- superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
- superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
- superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)
- D-serine degradation (2/3 steps found)
- L-cysteine degradation II (2/3 steps found)
- L-methionine biosynthesis I (3/5 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (12/18 steps found)
- glycine betaine degradation III (4/7 steps found)
- L-methionine biosynthesis II (3/6 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- seleno-amino acid biosynthesis (plants) (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glycine betaine degradation I (4/8 steps found)
- homocysteine and cysteine interconversion (1/4 steps found)
- superpathway of L-cysteine biosynthesis (fungi) (2/6 steps found)
- superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (4/10 steps found)
- glutathione-mediated detoxification I (2/8 steps found)
- purine nucleobases degradation II (anaerobic) (12/24 steps found)
- glutathione-mediated detoxification II (1/9 steps found)
- superpathway of seleno-compound metabolism (5/19 steps found)
KEGG Metabolic Maps
- Biosynthesis of plant hormones
- Cysteine metabolism
- Methionine metabolism
- Nitrogen metabolism
- Selenoamino acid metabolism
- Sulfur metabolism
Isozymes
Compare fitness of predicted isozymes for: 4.4.1.8
Use Curated BLAST to search for 4.4.1.13 or 4.4.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q8A083 at UniProt or InterPro
Protein Sequence (389 amino acids)
>BT4138 putative aminotransferase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482) MNYNFDEIINRNGTDSVKWDAVERRWGRNDLIPMWVADMDFRTAPFVIDALKKRLDHEVL GYTFACKEWAESIINWLKERHGWEIREDMLTFTPGIVRGLAFAIHCFTEKGDKVMVMPPV YHPFFLVTQKNEREVVYSPLVLKDGQYHIDFDRFRKDVQGCKLLILSNPHNPGGRVWTKE ELSQIADICYENGTLVISDEIHADLTLPPYKHPTFALISEKARMNSLVFMSPSKAFNMPG LASSYAIIENDELRHQFQVYMEASEFSEGHLFAYLSVAAAYSHGTEWLDQVVAYIKGNID FTESYLKERIPAIRMIRPQASYLIFLDCRELGLNQEELNRLFVEDAHLALNEGTTFGKEG EGFMRLNVACPRATLEKALRQLEQAVNNR