Protein Info for BT4111 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1511 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 912 to 933 (22 residues), see Phobius details PF07494: Reg_prop" amino acids 34 to 57 (24 residues), 18.1 bits, see alignment (E = 7.8e-07) amino acids 454 to 471 (18 residues), 19.6 bits, see alignment (E = 2.6e-07) amino acids 554 to 576 (23 residues), 22.1 bits, see alignment (E = 4e-08) PF07495: Y_Y_Y" amino acids 839 to 903 (65 residues), 74 bits, see alignment (E = 2.6e-24) PF00512: HisKA" amino acids 951 to 1015 (65 residues), 59 bits, see alignment (E = 1.4e-19) PF02518: HATPase_c" amino acids 1063 to 1170 (108 residues), 76.5 bits, see alignment 7.5e-25 PF00072: Response_reg" amino acids 1236 to 1345 (110 residues), 83.9 bits, see alignment 3.2e-27 PF12833: HTH_18" amino acids 1429 to 1507 (79 residues), 62.2 bits, see alignment 1.7e-20 PF00165: HTH_AraC" amino acids 1469 to 1506 (38 residues), 41.4 bits, see alignment (E = 4.2e-14)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_4111)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0B0 at UniProt or InterPro

Protein Sequence (1511 amino acids)

>BT4111 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MIKRILYLILLCLTAPVVQAQQHSFFTHYSTEDGLSQNTVMSMLQDHKDNLWFATWDGIN
RFDGYNFKTYKARQGNYISLTNNRADRMYEDRYGFLWLLTYDNRVHRFDPKTETFEQVPA
AGEEGSTYNIHAIQVLPDGTVWLLTEHDGAIRVVTLPQKNYTTKSDIYSTKSGLFPADHF
YQVYQDKAGNHWLLTDNGLGMIRPGEQQPVNYFVETKGKQDGMNQAFYAVRECEDDICFA
SDRGRIWCYQKQGGEFRLLELPTKARITSIHTVSNGNTVVTTDSDGFFLCNLKTNKHTHY
SPVTCKELSAQPILSAYVDRTSEVWFEQEEPGVVVHFNPATGVVRREQMRVEYSNADRSR
PAFHIHEDVHGHIWVHPYGGGFSYFDRDRNCLVPFYDDLGSNNWRFSNKIHAAFSDKQGN
LWLCTHSKGLEKVTFRNVPFSMLTPVPHEYESLSNEVRSVCEDKQGNLWVGLKDGMIRLY
DSNRKFIGHLTGNGTISMTGTPMEGTAYFIMQDSKGIIWIATKGNGLVRAEQISPTSMSY
KLTRYQHDSNDMYSLSDNNVYCVYEDHHGRIWAATFAGGINYISQGEHGETVFINHRNNL
KGYPIDVCYKARFITSDNNGRLWVGTTTGAVAFDENFKKPEDIQFHHFSRVPNDTKSLSN
NDVHWIIATQQKELYLATFGGGLNKLISISENGHGEFKSYSVLDGLSSDVLLSIREDHKQ
NLWISTENGICKFVPSGERFENYDERSISFRVRFSEAASTLTSGGDMLFGTSNGLFMFTP
DSIRKSSYVPPVVFSKLMVANEDVIPGEKSILKVDLDDTQELVLSHDENIFSVQYAALDY
TNPQNIQYAYILDGFEKQWTFADRQRSVTYTNLPKGDYIFRVRSTNSDGVWVDNERILNI
TILPSFWETPLAYVLYVCFVLLIIFVAVYILFTIYRLKHEVSVEQQISDIKLRFFTNISH
ELRTPLTLIAGPVEQVLKNDKLPADAREQLVVVERNTNRMLRLVNQILDFRKIQNKKMKM
QVQQLNVVAFVRKIMDNFESVAEEHNIDFLFQTEKEALNLWVDADKFEKIVFNLLSNAFK
YTPNGKMITVFIREDEGTVSVGVQDQGIGIAENKRKSLFVRFENLVDKNIFNQASSGIGL
SLVKELVEMHKATISVDSRLGEGSCFKVDFLKGKEHYNSSVEFILEDSVAPLSMERIVDI
ANSSLQTEAAIADAPDLEVSAVKEEAEESSSKELMLLVEDNQELRSFLRSIFASTYRVVE
ASEGMEGWSKALKYLPDIIISDVMMPEKDGIEMTRELRADMTTSHIPIILLTAKTTIESK
LEGLEYGADDYITKPFSATYLQARVENLLMQRKKLQNFYRDSLTHVTVSETPVAQGETLA
GHASAEPVSSAAEEPAMPEMSPNDRKFMDKLVDLMEQNMDNGELVVDDLVRELAVSRSVF
FKKLKTLTGLAPIEFIKEMRIKRAAQLIETGEFNMTQISYMVGINDPRYFSKCFKAQVGM
TPTEYREKVGR