Protein Info for BT3969 in Bacteroides thetaiotaomicron VPI-5482

Annotation: cation efflux system protein, AcrB/AcrD/AcrF family protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1441 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 341 to 360 (20 residues), see Phobius details amino acids 367 to 387 (21 residues), see Phobius details amino acids 397 to 420 (24 residues), see Phobius details amino acids 442 to 465 (24 residues), see Phobius details amino acids 478 to 499 (22 residues), see Phobius details amino acids 540 to 559 (20 residues), see Phobius details amino acids 874 to 894 (21 residues), see Phobius details amino acids 901 to 920 (20 residues), see Phobius details amino acids 926 to 949 (24 residues), see Phobius details amino acids 975 to 995 (21 residues), see Phobius details amino acids 1007 to 1030 (24 residues), see Phobius details amino acids 1046 to 1064 (19 residues), see Phobius details amino acids 1318 to 1331 (14 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1034 (1034 residues), 1104.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1033 (1029 residues), 897 bits, see alignment E=1.5e-273 PF02321: OEP" amino acids 1074 to 1244 (171 residues), 31 bits, see alignment E=2.3e-11 amino acids 1283 to 1435 (153 residues), 44.4 bits, see alignment E=1.7e-15

Best Hits

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 100% identity to bth:BT_3969)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A0Q2 at UniProt or InterPro

Protein Sequence (1441 amino acids)

>BT3969 cation efflux system protein, AcrB/AcrD/AcrF family protein (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MFKAIVRFSIRKKLFVGLTTLFLFIGGIYAMLTLPIDAVPDITNNQVQIVTVSPTLAPQK
VEQLITMPIEIAMSNIMNVEDIRSVSRFGLSVVTVVFKEDVPTLDARQLINEQIQTVSGE
ISPELGTPEMMPITTGLGEIYQYILKVAPGYEEKYDAMELRTIQDWMVKRQLSGIPGIVE
INSFGGYLKQYEVAVDPDALFSLNITIGEVFEALSSNNQNTGGSYIEKAKNAYYIRSEGM
ITRIKDIEQIVVANRNGIPVHISDVGAVRFGAPKRFGAMTMDGKGECVGGIAMMLKGANA
NVVTQELEKRVEKIQHLLPEGISIEPYLNRSELVNRNISTVVNNLIEGAIIVFLVLIIFL
GNVRAGLIVASVIPLAMLFAFIMMRLFNVTANLMSLGAIDFGIVVDGSIVILEGILAHIY
SKQFRGRTLTRKEMDEEVEKGASGVVRSATFAVLIILIVFFPILTLNGIEGKYFTPMAKT
LVFCIIGALILSLTYVPMMASLFLKHTIVVKPTLADRFFEQLNKLYQRCLHACLHHKART
VVIAFAALIGSLFLFTRLGAEFIPTLDEGDFAMQMTLPAGSSLSESIKLSEEAEKTLMDQ
FPEIKHVVAKIGTAEVPTDPMAVEDADVMIIMKPFKEWTSATSRAEMVEKMKEALEPLSE
RAEFNFSQPIQLRFNELMTGAKADIAVKLYGEDTHELYQRAKEAATYVEKVPGAADVIVE
QTMGLPQLVVKYNRGKIARYGINIEELNTIIRTAYAGEASGVVFENERKFDLVVRLDQEK
VADLNLDKLFVRTSEGIQIPVGEVASIELVSGPLQINRDATKRRIVIGVNVRDADIQQVV
ANIQKTLDKNIKLQPGYYFEYGGQFENLQNAINTLMIVIPVALMLILLILFFAFKNITYT
LMVFSTVPLSLIGGIVALWLRGLPFSISAGVGFIALFGVAVLNGILMVNHFNELRKRNKY
AMTTNRILTLGTPHLLRPVFLTGLVASLGFVPMAIATSAGSEVQRPLATVVIGGLIISTV
LTLLIIPVFYKIVNSFAVWRRPGSKFHLPFFVILPLLLLIPSFASAQQPEAVSLEQAIEI
AKQNHPRLKIAANAIRQAKATRGEIVEAAPTSFNYSWGQLNGENKQDKELAFEQSLGSLL
TPFYKNALVSRQVKTSTYYRRMVEKEVIAEVKRAWAYYQYAANLCSMYRDQDKMAEELKR
IGEIRYQQGEITLLEKNMMTTTAADLHNRWYQAQEEEKTALARFQWCCYADSPIVPADST
LSLFYTTLSDGNLSEAHTGYFRSQAEEAKAMLHVERSHFFPEISIGYTRQDILPLKSLNA
WMVGVSFPVYFLPQKSKVKQARLAAASAQIQADANIRELRNKVMELEASLRRYNESLRYY
TTSALKEAEELTKAANLQLQQSETGVAEYIQSVTTARDIRRGYIETVYQYNIAALEHELF
E