Protein Info for BT3851 in Bacteroides thetaiotaomicron VPI-5482

Annotation: DNA mismatch repair protein mutL (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 640 TIGR00585: DNA mismatch repair protein MutL" amino acids 5 to 306 (302 residues), 296.1 bits, see alignment E=2.1e-92 PF02518: HATPase_c" amino acids 23 to 85 (63 residues), 33.7 bits, see alignment E=8.9e-12 PF13589: HATPase_c_3" amino acids 26 to 126 (101 residues), 45.8 bits, see alignment E=1.3e-15 PF01119: DNA_mis_repair" amino acids 209 to 326 (118 residues), 120.6 bits, see alignment E=5.8e-39 PF08676: MutL_C" amino acids 460 to 596 (137 residues), 98.1 bits, see alignment E=7.8e-32

Best Hits

Swiss-Prot: 100% identical to MUTL_BACTN: DNA mismatch repair protein MutL (mutL) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 100% identity to bth:BT_3851)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A120 at UniProt or InterPro

Protein Sequence (640 amino acids)

>BT3851 DNA mismatch repair protein mutL (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MSDIIHLLPDSVANQIAAGEVIQRPASVIKELVENAIDADAQNIHVLVTDAGKTCIQIID
DGKGMSETDARLSFERHATSKIREAADLFALRTMGFRGEALASIAAVAQVELKTRLESEE
LGTKLVIAGSKVESQEAVSCSKGSNFSVKNLFFNVPARRKFLKANSTELSNILAEFERIA
LVHPEVAFSLYSNDSELFNLPVSPLRQRILAIFGKKLNQQLLNIEVNTTMVKISGYIAKP
ETARKKGAHQYFFVNGRYMRHPYFHKAVMEAYEQLIPVGEQVSYFIYFEVDPANIDVNIH
PTKTEIKFENEQAIWQILSASVKESLGKFSAIPSIDFDTEDMPDIPAFEQNLPPAPPKIH
YNSDFNPFKVSSGGSGGGSYSRPKVEWEGLYGGLTKASKMNEPQQEPEMDWENSPFEEEP
MVAEEKTISAVSAASSTFSSASSTLYANESVIEKGNLHLQFKGRFILTSVKSGLMLIDQH
RAHIRVLFDRYMVQIKQKQGVSQGVLFPEILQLPASEAAVLQGIMDDLSAVGFDLSDLGG
GSYAINGIPSGIEGLNPVELVRNMLHTAMEKGNDVKEEIQNILALTLARAAAIVYGQVLS
NEEMVSLVDSLFACPSPNYTPDGKTVLTTIKEEDIEKLFK