Protein Info for BT3810 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative endothelin-converting enzyme (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 214 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF05649: Peptidase_M13_N" amino acids 42 to 213 (172 residues), 163.4 bits, see alignment E=5.8e-52

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3810)

Predicted SEED Role

"Endothelin-converting enzyme 1 precursor (EC 3.4.24.71)" (EC 3.4.24.71)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.71

Use Curated BLAST to search for 3.4.24.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A157 at UniProt or InterPro

Protein Sequence (214 amino acids)

>BT3810 putative endothelin-converting enzyme (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKVTKYLPILAVCLMTTGCNSKKEAVLTSGIDLANLDTTAMPGTSFYQYACGGWIESHPL
TDEYSRFGSFDMLHEKSREQLKELIAELAAKKDNAPGSAAQKVGDLYNIAMDSVKLNKEG
AAPIKEEMAAIDALKDKEEIYTYIAESQKKGIRPYFTMFVSADDMNSSMNMVQTYQGGLG
MGQRDYYLENDEQTKSIRDKYKEHLVKMFQLAGL