Protein Info for BT3786 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1345 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 779 to 801 (23 residues), see Phobius details PF07494: Reg_prop" amino acids 35 to 54 (20 residues), 19.7 bits, see alignment (E = 2.4e-07) PF07495: Y_Y_Y" amino acids 708 to 771 (64 residues), 59.4 bits, see alignment 8.9e-20 PF00512: HisKA" amino acids 827 to 892 (66 residues), 39.8 bits, see alignment 1.3e-13 PF02518: HATPase_c" amino acids 938 to 1051 (114 residues), 61.4 bits, see alignment E=3.7e-20 PF00072: Response_reg" amino acids 1093 to 1199 (107 residues), 74.3 bits, see alignment E=3.2e-24 PF12833: HTH_18" amino acids 1260 to 1338 (79 residues), 65.6 bits, see alignment 1.4e-21 PF00165: HTH_AraC" amino acids 1301 to 1338 (38 residues), 27.6 bits, see alignment (E = 8.9e-10)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3786)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A180 at UniProt or InterPro

Protein Sequence (1345 amino acids)

>BT3786 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKHCILLFFCCLNLLMNTAGAYNLKQVADKEYMSNSSITSLCQDDKGLMWIGTCDGLNI
YDGQEIEEFKTRDKEDYLSGNQIDNIIYTGNDTYWFQTYYSLIRLDRKTNSITRFNEFQK
LFLMNKDNHSTLFIIKDTNCIYYFHKKEGIFKKINVTGIPISDVITFFFDKNNRMWVMMK
GYNRCYDLQQDPLTENITLVSQKSGLDHHTPLICSFYDDAAVYYVDKEYNLYAFHIESKK
NEFIANLGANIQAHDKISSIVKYHDSFFVGLMMDGVLTLEKQKGSGEYQIQTLPINSGTF
SLIKDRFQDVVWIGTDGQGVYLYSNPLYSIKSVVLNNYTEKIERPVRALLLDKERTFWIG
TKGNGILKIFDYEVQKNISDCRSEILTTSNSGLGSNAVYCIRESNRNLLWIGDEEGLNFY
SYRERRIKKLPLWIDNEEFKYIHDIYETEDSELWLASVGMGVVRARIGGTPDHPVLEKLQ
RYVVNGGEFGSNYFFTICKGDSLNLLFGNMGYGVYRFNETINGLEPLTTHKYENMNLNKV
VPIIKDDADNYLIGTTYGVIKYASENSYQLFNAKDGFLNSTIHAILRHSSDNFWLSTNQG
LINFDTKRNVFRSYGFGDGLKVVEFSDGASYRDPQTGILFFGGINGFVAIQADGRPEQLY
MPPIYFDKLSIFGEQYNLGEFITRKKENEVLNLKYDQNFFAVSFTSVDYLNGNNCTYSYK
LKGLSDQWINNGKESSVSFTNMAPGEYTLLVKYYNSVFDKESEVYSLLIRIGDPWYASWW
AYLIYSLCLLMIAAMLVRSFILRTKRKKQELLNEIEKRHQKNVFESKLRFFTNIAHEFCT
PLTLIYGPCGRILSSKGLSKFVVDYVQMIQTNAERLNNLIHELIEFRRIETGNREVRIEA
LNVSSLMKNTAKTFVDMAKSRNITFLSKIPEQVSWNSDKGFLNTIIINLISNAFKYTPDG
KSIKIEVDTNDENLLVLRVANEGSTIKEEDFQYVFNRYAILDSFENQDEKNFSRNGLGLA
ISYNMAKLLNGTLKVENTPDGWVLFTLSLPPLEVTTGVSSSKRITSEYIPKIESQLVLKL
PHYEFDKMRPTLLVIDDELEMLWFIGEIFSNDFNVVTLQEPERVEQVLNEVYPNVIICDI
MMPGVGGIELTKRIKSVKETSHIPIIMVSGRHEMEQQMAALSAGAEMYITKPFNAEYLRI
SVCQMLERKEVLKDYFSSAISSFEKTDGKLTHKESKKFQQSVLKIINDHIQEKELTPRFI
ADHLAISVRSLYRKMEEMGEESPTIMIKECRLYVAKDLLLKTKKTIDEIVFEAGFSNKVT
FFKVFREKYGCTPKEFRTKHLEEVQ