Protein Info for BT3680 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1033 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 24 to 1033 (1010 residues), 1033.5 bits, see alignment E=0 PF13620: CarboxypepD_reg" amino acids 25 to 84 (60 residues), 37.7 bits, see alignment 3.3e-13 PF13715: CarbopepD_reg_2" amino acids 26 to 108 (83 residues), 65.3 bits, see alignment E=6.2e-22 PF07715: Plug" amino acids 118 to 221 (104 residues), 57.7 bits, see alignment E=2.4e-19 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 197 to 227 (31 residues), 64.4 bits, see alignment (E = 5.9e-22)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3680)

MetaCyc: 48% identical to SusC-like TonB-dependent receptor monomer (Bacteroides thetaiotaomicron)
RXN-23727; TRANS-RXN-1546

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A1I1 at UniProt or InterPro

Protein Sequence (1033 amino acids)

>BT3680 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKRSILVLFWVFMSATMFAQGGIDVAGIVLDEQGQELIGVSVQIKGKQGVGVVTDFDGRF
KITGVPAGSTLVFSYIGYETREIKYTATKLKEKIALKEAVNEFDEVVVVGRDTQRKVSVV
GAITNVDPAGIQAPAVSVSNMLGGRVPGIIAVTRSGEPGNNFSEFWIRGMSTFGASSSAL
VLIDGIEGNINDLDPADIESFSILKDASATAVYGTRGANGVVVVTTKRGKAGKLHVNFKT
NATYSYSPRMPEYADAYQYATLANEARSVRGDDPVYSATELELFKTGLDPDLYPNVNWRD
VILKDHVINNQHHLSISGGGQSARYYMSLGILNSEALFKQDKSASKHDVNVNYHKYNFRT
NIDADLTKTTLLSLNLEAVIKTQNAPGTGSSNKYLWESQANLPPTVVPVRYSNGQLPAYG
TNLEDKSPYVRLNYMGYTTNETYSTKINVGLSQDLGMITEGLSVRGLFSFSMNGAHIVDR
HMNPEQYYADPKDGRYLDGSLKTVRTVNKEDMTATQGSASNRELYFEAAANYKRLFNQDH
RVTGLAHFYRQELTNVDWGNGVLVSIPKRYQALSFRATYSYKDTYLVEGNLGYTGSENFN
KERRYGWFPSISGGWVPTQYDWYRNLLPFNNFLKFRASWGRVGNDRLKDENGNDIRFPYL
TTLGNVSSTWGTGLAENRTGSMNLKWEVSTKTNFGIDARFFDDKVDMTVDFFHTKTTDIF
QRRANIPDEGGLSNVLPYANIGSMKSWGMDGTLAYTHTFNKDMALTVRGNFTHAENEVIY
WEQSGVNYPYQSNSGVPYKVQRGLIALGLFKDEDDIKSSPKQTFMDNYRPGDIKYKDVNG
DGKIDKDDVVPLNYSAVPFIQYGFALDWNYKAFRVSILFEGVSKVQYFQGGRGFYPFLNE
SRGNLLEMVADPRNRWIPREYAEVNGIDPALAENPNAKFPRLTYGENKNNNQESTFWLAD
GKYLRLKNVDVSYRFTNNWLKSRVGVESATLSLIGENLHVWDKVKLFDPSQASGNGAEYP
LQRMYTLQLNLTF