Protein Info for BT3302 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1366 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 784 to 810 (27 residues), see Phobius details PF07494: Reg_prop" amino acids 45 to 66 (22 residues), 19.2 bits, see alignment (E = 3.6e-07) amino acids 354 to 373 (20 residues), 19.3 bits, see alignment (E = 3.3e-07) amino acids 585 to 607 (23 residues), 18.2 bits, see alignment (E = 7.2e-07) PF07495: Y_Y_Y" amino acids 717 to 780 (64 residues), 55 bits, see alignment 2.2e-18 PF00512: HisKA" amino acids 836 to 901 (66 residues), 27.6 bits, see alignment 8.6e-10 PF02518: HATPase_c" amino acids 948 to 1060 (113 residues), 78.8 bits, see alignment E=1.4e-25 PF00072: Response_reg" amino acids 1101 to 1211 (111 residues), 75.6 bits, see alignment E=1.2e-24 PF12833: HTH_18" amino acids 1270 to 1347 (78 residues), 72.8 bits, see alignment 7.9e-24 PF00165: HTH_AraC" amino acids 1309 to 1347 (39 residues), 32.4 bits, see alignment (E = 2.8e-11)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3302)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A2K3 at UniProt or InterPro

Protein Sequence (1366 amino acids)

>BT3302 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKHNEWTKRTTLLRRVLLILVSFLLIGVDINASYSLRQFSSKNGLSNSAILSMCQDRHG
VIWIGSCDGLNIYDGTYLGLYKPTNVHHSFSGNLIERIIEADNDVLWIQTNYGLDRFDTR
RQTIQSFKDFKYINRMAISPEDDFFIIKDDGYIYYYQPEQKDFCKLDVKKIHFEEVQQMA
IDNFGVLWIFSSDNDNRSYIIEKNGNQVKLVPSNCLNHSEKLLWTFVDGDFLYFIDSTYA
LYEYDLNNHKAYFIADMEAEILRRGEVSSIIKQKTDYFIGFKSSGLIQLKYMPDSKVKYS
LQSINVQSGIFCLMKDRFQDIIWVGADGQGLYMYFTDEFSIDNIMLDVPEYRVDNPVRAL
YQDQDQTLWIGTKGGGILKMFDFHPDMETLPRAERILASNSPLMDNSVYSFAPSRRKLLW
IGTESGLNYYSYSQKRIQEFPVMADGKMVKYVHSVRETNDSTLWVVSAGEGIVKIILDAT
SLLPKVKSARRFTLDGGKRNSNYFFVSFQENDSVIWFGNRGYGAYKMNTHTNQLTPCRID
DVVKNQTVNDIFAIHKNDEGYWFGTSFGLTRLYQGEYRVYNETDGFPNNTIHGILEGRDN
NLWLSTNQGLVRFNVRENTVQTYRQQGDLEVIEFSDGAFFKDQQTGTLFFGGTNGFITIS
ENDQLSEEYMPPLHFNRLSIFGKECNIYDFLQGATKQETLVLDYSQNFFNLSFIAVDYIN
GNNYTYSYKIDGLSDSWIENGLSTVAVFSNLSPGEYTLLVKYRSNITGKESEPYSLLIRI
TPPWYMTTCAYIVYFLLLAGVIAGAIRMVIKRYRRKRNVMIEEMNRQQREELYESKLRFF
TNITHEFCTPLTLINGPCEKILSYSRVDSYVRKYASMIQQNALKLNALILELIEFRRLET
GNKILKIKHVPVTEQIRTIAESFGELAESRKLNYRLQIEDGVFWNTDVSCLSKIVNNLIS
NAFKYTPENGSITVELRIEGEQLCIRVSNTGKGIKEADLTKIFDRYKILDNFEVQNKNGI
SPRNGLGLAICHSMVNLLNGQIQVSSIPNEVTTFDVWLPVMEVTVDNEDEKVAEELVLSS
DEQAVELKNSSVEFDKNKQTIMIIDDDPSMLWFVTEIFVGAYNVVSLGSAEEALKQLGIQ
LPDLIISDVMMPGMDGMSFAKKIKSDKLLSRIPLILLSALNNIDEQTRGIESGAEAYITK
PFNVEYLEKVVRRLLQREEDLKEYYSSVLSAFELDDGHFLHKEDKSFFEKMMQIIDSHIQ
NTDLSVELLSSSLGYSTRQFYRKLKNVTEKTPADIIREYRLTIVERLLLTTQLSIEEIMD
KTGFSNRGTFYKAFAQKFEMTPKQYRNIKTKDVHEASEEGGGTMNV