Protein Info for BT3172 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1310 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 755 to 774 (20 residues), see Phobius details PF07494: Reg_prop" amino acids 40 to 59 (20 residues), 18.9 bits, see alignment (E = 5.1e-07) amino acids 82 to 104 (23 residues), 16.1 bits, see alignment (E = 4e-06) PF07495: Y_Y_Y" amino acids 689 to 749 (61 residues), 40.4 bits, see alignment 8.7e-14 PF00512: HisKA" amino acids 800 to 863 (64 residues), 42.8 bits, see alignment 1.8e-14 PF02518: HATPase_c" amino acids 912 to 1020 (109 residues), 78 bits, see alignment E=3e-25 PF00072: Response_reg" amino acids 1059 to 1170 (112 residues), 90.8 bits, see alignment E=2.7e-29 PF12833: HTH_18" amino acids 1227 to 1305 (79 residues), 71.9 bits, see alignment 1.8e-23 PF00165: HTH_AraC" amino acids 1268 to 1303 (36 residues), 45.6 bits, see alignment (E = 2.3e-15)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3172)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A2Y3 at UniProt or InterPro

Protein Sequence (1310 amino acids)

>BT3172 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKTRLLTLPGIIAIILLITTLPLRAEHYYYKQISLKEGLPSNVRCILRDEQGFIWIGTKA
GLGKFDGHQLKRYKHQANDPHSLLHNLIYQIAEDKQHNIWILTEKGIARYQQQSNNFTFP
TDEEGNYITAYSFCLVPDGILFGGKDRIYKYSYKDSSLRLLQYFNANSFKITALSVWDSK
TLLCCSRWTGLYLVDLQTGEHRRPPFDCGPEITSMITDSKNRIWIAPYSGGLRCYSRDGK
LSASYTTHNSSLSNDIVLSLAEREEQLWIGTDGGGINILHPETGEISQLEYIPGRENYSL
PANSILCLHNDYNNNVWAGSTCNGLISIREVSMKTYTDVVPGNDRGLSNGTVRSLYRQSP
DSIWIGTDGGGINLFSPHTEKFTHYSSTWGDKVAFISGFTPGKLLISLFSKGVFVFNPAT
GEKQPFTIIDKETTTRLCNRGKSVNLYQNTPNTVLFLGDHIYQYHLKEKKFSTITEEEGK
DIVGTLVPFDHQENLTYINDIKHIYELDDQTSRLKTVFECYTDTVISSVSHDEQGHFWIG
SNFGLIHYDPVLKSRTLVPTNLFTEINMVLCDQKGKVWIGVDNMLFAYFIKEQKFVLFGE
SNGAIQNEYLPNARLVNEQGDAYIGGVKGMLRIDGQLLLNTSEMPELQLLDITINGESAN
HEWYNHPAKISVPWNSNISIRIMSREEDIFRQKIYRYQIEGLNNEYTESYNPELVIRSLL
PGSYRIMASCTAKDGSWIPDQQVLELTVLPPWYRTWWFSLTCAVLVSIAIIETFRRTVKR
NEEKLKWAMKEHEKQTYEEKVRFLINISHELRTPLTLIHAPLNRILKSLSSEDPQYLPLK
AIYRQAQRMKNLINMVLDVRKMEVGESKLLIQPHPLNHWIEHVSQDFISEGEAKNVRIRY
QLDPQIETVSFDKDKCEIILSNLLINALKHSPQDTEITIASELLPETGRVRISIIDQGCG
LKQVDTHKLFTRFYQGTGEQSGTGIGLSYSKILVEQHGGSIGAQDNPEAGAIFFFELPLK
QESEEIICQPKAYLNELILSDNLKQATDKETFDTTPYTILVVDDNPDMTDFLKKTLEESF
KRVIIAADGVEALQLIKSHIPDIIVSDVMMPRMNGYELCINIKEDITISHIPIILLTARD
DKQSLISGYKNGADAYLTKPFEVEMLMEIISNRLKNREYIKKRYLHTGIIPVPKETTFSQ
VDESFLLKVNKTIQENLSNTNLDIQFICKEIGLSRTSLYTKLKALTGIGANDYINKFRIE
KALTLIANTEMTFTEISEEVGFTSPSYFSTAFKQYTGETPTQYKEKTSKI