Protein Info for BT3049 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1376 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 796 to 817 (22 residues), see Phobius details PF07494: Reg_prop" amino acids 32 to 54 (23 residues), 23 bits, see alignment (E = 2.3e-08) amino acids 224 to 246 (23 residues), 27.4 bits, see alignment (E = 8.4e-10) amino acids 326 to 349 (24 residues), 16.3 bits, see alignment (E = 3.4e-06) amino acids 376 to 399 (24 residues), 19.2 bits, see alignment (E = 3.9e-07) amino acids 421 to 442 (22 residues), 19.4 bits, see alignment (E = 3.5e-07) amino acids 509 to 531 (23 residues), 22.3 bits, see alignment (E = 4e-08) amino acids 596 to 618 (23 residues), 21.8 bits, see alignment (E = 5.7e-08) PF07495: Y_Y_Y" amino acids 728 to 791 (64 residues), 65.5 bits, see alignment 1.3e-21 PF00512: HisKA" amino acids 847 to 911 (65 residues), 47.2 bits, see alignment 7.7e-16 PF02518: HATPase_c" amino acids 960 to 1067 (108 residues), 85.9 bits, see alignment 1e-27 PF00072: Response_reg" amino acids 1111 to 1220 (110 residues), 81.6 bits, see alignment E=1.9e-26 PF12833: HTH_18" amino acids 1287 to 1366 (80 residues), 69.6 bits, see alignment 9.2e-23 PF00165: HTH_AraC" amino acids 1331 to 1365 (35 residues), 28.6 bits, see alignment (E = 5.1e-10)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_3049)

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A3A5 at UniProt or InterPro

Protein Sequence (1376 amino acids)

>BT3049 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKTYIAAFFLLLSATFVAAHPYLIQRLGIEQGLSNNYVLSITQDKQGFLWFATEEGLNKF
DGTRFITYYKEEQSSSVQSITGNELNEVYTDPVQPVIWIATQRAGLNAYNYETQSFSVYQ
YNPEDPQSLITNDVTHITSSVQAGKGLWVCTYYRGIEYLDIATGKFTHYNKSTVPALPSE
QTWTATEAEDGKLYIGHVEGGLSILSLNDKSVKHFVHDPQNPNSLPGNDVRCIYKDTNGN
IWIGTSKGLALFNANTETFTNFHNNPGNIHGALSSYIFSIKQLKDNKLWIATELNGIMIL
DLQQNQFLLPEQIRFEFIREGDNNYSLSNASARYIFQDSFNNIWIGTWGGGINFISNAPP
TFHTWSYSPTQMNESSLSNKVVSSVCDDGQGKLWIGTDGGGINVFENGKRVAIYNKENRE
LLSNSVLCSLKDSEGNLWFGTYLGNISYYNTRLKKFQIIELEKNELLDVRVFYEDKNKKI
WIGTHAGVFVIDLASKKVIHHYDTSNSQLLENFVRSIAQDSEGRFWIGTFGGGVGIYTPD
MQLVRKFNQYEGFCSNTINQIYRSSKGQMWLATGEGLVCFPSARNFDYQVFQRKEGLPNT
HIRAISEDKNGNIWASTNTGISCYITSKKCFYTYDHSNNIPQGSFISGCVTKDHNGLIYF
GSINGLCFFNPDIAINSPQIPPVVITKVRIPGRLTSREKNETAIPISEGEIELTHEQNSF
NLTFNVQDYSLANQVEYAYMLKGLENSWYTINEQNSVTFRNIPPGKYEFLVKARLHNQDW
SEDTTSLRIHINPPLWLTWWAKLIYILITISIIYTIIHAYKKKIDLESLYTLEKKNHEQE
QELNQERLRFYTNITHELRTPLTLILGPLEDMQKDTSLPTRQAQKLSVIHLSALRLLNLI
NQILEFRKTETQNKKLCVCKGNIVPLIHEIGLKYKELNQKKAIDFQIQIEKEEMPLFFDK
EIITIILDNLISNAIKYTEQGKITLSLYPTTRNGVTYTEIKVSDTGYGISAEALPHVFDR
YYQESGKHQASGTGIGLALVRNLVELHEGEIRVESIQNEGSTFYISLLTDNIYPNALHGD
STKQTEEEMISEAVPEDSQNTEPETSKPILLIVEDNEDIQKYIAESFSDSFEVITGSNGE
EGKQQALNRIPDIIVSDIMMPVMDGITLCRQLKEDVRTSHIPVILLTAKDSLQDKEEGYE
VGADSYLTKPFSASLLRSRINNLLDSRKKLIAQFQQTGTNHNPNSHLDEKRSIITEALSK
LDNEFIEKITQLVEDNLSSEKIDITYLSDKMCMSGSTLYRKMKALTGLSTNEYIRKVKMQ
NAERLLLEGKYNISEIAYKIGMNSTGYFRQCFKDEFGVSPSDYLKQFTSPTPPPSS