Protein Info for BT2940 in Bacteroides thetaiotaomicron VPI-5482

Annotation: multidrug resistance protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 367 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 38 to 367 (330 residues), 249.4 bits, see alignment E=2.1e-78 PF25917: BSH_RND" amino acids 62 to 202 (141 residues), 54.2 bits, see alignment E=3.2e-18 PF25944: Beta-barrel_RND" amino acids 208 to 284 (77 residues), 38 bits, see alignment E=5.5e-13 PF25967: RND-MFP_C" amino acids 298 to 357 (60 residues), 22.4 bits, see alignment E=2.9e-08 PF25989: YknX_C" amino acids 300 to 367 (68 residues), 40.2 bits, see alignment E=7.5e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2940)

Predicted SEED Role

"Multidrug resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A3L4 at UniProt or InterPro

Protein Sequence (367 amino acids)

>BT2940 multidrug resistance protein (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MITVNKKWIRLIGIVGCTVWMASCKQAPDAGVKSSYAVMQIEPTDKELSSSYSATIRGRQ
DIDIYPQVSGTIEKLCVTEGQKVRRGQLLFIIDQVPYRAALKTATANVEAARAATSTAEL
TYKSNKELYAQKVVSEFSLKTAENSYLTAKAQLAQAEAQEISARNNLSYTEVKSPSDGVV
GALPYRAGALVSANIPYPLTTVSDNSDMYVYFSMTENQLLALTRQYGDMDEALKNMPEVE
LILNDNSVYQKKGTIESISGVIDRQTGTVVARVVFPNESRLLHSGASGTVVVPSIYKNCI
AIPQTATVRMQDKTIVYKVVDGKAVSTLITVAGINDGREYVVLDGLKAGDEIVSEGAGLV
REGTQVK