Protein Info for BT2805 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1083 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details PF13620: CarboxypepD_reg" amino acids 45 to 115 (71 residues), 39.8 bits, see alignment 1e-13 PF13715: CarbopepD_reg_2" amino acids 45 to 127 (83 residues), 49.7 bits, see alignment 6.1e-17 TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 45 to 1083 (1039 residues), 938.7 bits, see alignment E=5.3e-286 PF07715: Plug" amino acids 135 to 243 (109 residues), 68.6 bits, see alignment E=1.3e-22 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 219 to 249 (31 residues), 57.3 bits, see alignment (E = 1e-19) PF00593: TonB_dep_Rec" amino acids 449 to 1043 (595 residues), 60.5 bits, see alignment E=5.9e-20

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2805)

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A3Z9 at UniProt or InterPro

Protein Sequence (1083 amino acids)

>BT2805 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKTNRHSTLLKKAVHLITYNSSHKLICLLGYLLLCSMNTYAQNYVSGTVKDNNGEPLLGV
SIKVKDGNIVSGTVTDFNGHYQVKADPSSTIEFSYIGFKTVQFTVGDRKMINVTLGVDDN
LLDEVIVVGYGTQKKINLTGSVGVIDSKAFEAIPVSNAVQALQGQVPGLNIYSNQGGGLN
QKQSINVRGVGTIGEGSTGSALVLIDGMEGDIYSINPQDIESISVLKDAAASSIYGSRAP
FGVILVTTKKGKAGKAQVNYNNSFRVSSPINMPSSLDSYTFSLYYNDAAANSGWGPYNWV
SEERINRIKDYMAGKITDSTIPVPNNPSLWADGYSQGNDNIDYYDYFFKDNVFAHEHNIS
VTGGTDKIQYYLSANYLGQDGELRIGDEYSNRYTASAKINAQLSKIVSVGFNTRFIRSDY
VQPTHLNESFFAEIGRQCWPTKPLYDPNGILYDDHVLQMQNGGEKQERNTWLYQQLNITV
EPIKGWRLIGDLSYRYNTQYSHWDYLTVHQTGVDGKTKGNTWNNDSQVHEGTYASDYFNV
NLYTDYAKTFAKSHNMKVLFGFQAEQNNYKDIAAEKLGVIYPGKPTINTSTGMDSNNQKV
APNVAGGHNRWATAGFFGRLNYDYLEKYLLEVNLRYDGSSRFRSDSRWGFFPSASVGWNI
AREKFFLPVSKVVNTFKVRASYGSLGNQNTSSLYPTYSTIGTGTGSWIIDGTLANIAWAP
SLVSYNLSWEKIRTWNAGVDFGLFNNRLTGSFDYYIRKTDDMVGPSEKLPVVLGTAVPSS
NNTNLKTFGWELELMWKDRLNNGLNYSARFTLADSRTKITRYSNPSGLIDGFYAGKYVGE
IWGYETIGIAQSDQEMAEHIGRLINGGQSNLGQDWKAGDIMYKDLNEDGKIDAGSRTLQD
HGDLKRIGNSTPRYNVGLELAADWKGFDIRMFWQGTLKRDYFQGSYYFWGANGRQGPWFS
TALKGHDDYFRNDEASPLGTNLNSYYPRPLFNTDKNQQSQTKYLQDASYLRLKNLQIGYS
LPHNIVQKMGMQHLRIFASGENLFTITSLIDFFDPESIEGGSWGHGNVYPLSRTFSFGLN
VTF