Protein Info for BT2618 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system response regulator (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 PF00072: Response_reg" amino acids 4 to 113 (110 residues), 82.8 bits, see alignment E=5.2e-27 PF00158: Sigma54_activat" amino acids 130 to 294 (165 residues), 213.5 bits, see alignment E=4e-67 PF14532: Sigma54_activ_2" amino acids 130 to 299 (170 residues), 62.7 bits, see alignment E=1.1e-20 PF07728: AAA_5" amino acids 152 to 270 (119 residues), 28.3 bits, see alignment E=4e-10 PF02954: HTH_8" amino acids 387 to 423 (37 residues), 41 bits, see alignment 3.1e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2618)

Predicted SEED Role

"Response regulator of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4I1 at UniProt or InterPro

Protein Sequence (426 amino acids)

>BT2618 two-component system response regulator (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKNILIIEDDVVFSRSISNWLKKKGMATGHVSTLSAARKELQVKKFDLVLADLRLPDGSS
MELLKWMKGKYYSIPFLIMTSYGQVENAVEAMQLGASNYLCKPVQPDRLWEVIEKEFSRP
QHGSTEFYRGESEKAREMYRLIGPVARSDMSVLLRGASGTGKEHIAAEIHEWSLRRHKPF
VAVDCGAVSDDLVRSEFFGYCKGAFTGADSDKAGLFQAAEGGTLFLDEIGNLAPVNQMKL
LRALQEKRYLPVGTVRERPFDIRLIAATNADLEKAIAEGSFREDLYHRLNEFTIRVPLLS
ECGEDILPLAEFFLKQFSARYGKPVQGFDREAAAVLRQYGWPGNIRELKNTVRRAVVFAG
EGRISAQELNLDQGMKLGNMIVCPEKEEQQILRILGQTGNNRTLTARVLGISRTALYYKL
RKYGIV