Protein Info for BT2497 in Bacteroides thetaiotaomicron VPI-5482

Annotation: membrane fusion efflux protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 37 to 354 (318 residues), 147.8 bits, see alignment E=1.8e-47 PF16576: HlyD_D23" amino acids 46 to 260 (215 residues), 47.3 bits, see alignment E=2.3e-16 PF13533: Biotin_lipoyl_2" amino acids 62 to 107 (46 residues), 25.7 bits, see alignment 1.2e-09 PF13437: HlyD_3" amino acids 178 to 287 (110 residues), 38.6 bits, see alignment E=2.3e-13

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 100% identity to bth:BT_2497)

Predicted SEED Role

"Membrane fusion efflux protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A4V0 at UniProt or InterPro

Protein Sequence (366 amino acids)

>BT2497 membrane fusion efflux protein (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKYLKITLLVIIAIILVGTFVFLYQKSKPKVIVYETLAAEVTDLEKTTVATGKVEPRDE
ILIKPQISGIVDEVFKEAGQSVKKGEVIAKVKVIPELGQLNSAESRVRLAEINAKQAETD
FTRIKKLYEDQLISREDYEKGEVAVKQAREENQTAKDNLEIIKEGITKNSASFSSTMIRS
TIDGLILDVPVKAGNSVIMSNTFNDGTTIATVANMNDLIFRGNIDETEVGRIHEGMPIKL
TIGALQNLTFDAILEYISPKGVETNGANQFEIKAAITVPDTVQIRSGYSANAEIVLQRAS
KVLAVPESTIEFSGDSTFVYIMTDSVPQQKFERTQVTTGMSDGIKIEIKKGVTAQTKLRG
AEKKDK