Protein Info for BT2119 in Bacteroides thetaiotaomicron VPI-5482

Annotation: transmembrane protein precursor, possibly involved in transport (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 32 to 343 (312 residues), 190.8 bits, see alignment E=1.5e-60 PF25917: BSH_RND" amino acids 60 to 178 (119 residues), 42 bits, see alignment E=3.3e-15

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_2119)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A5W7 at UniProt or InterPro

Protein Sequence (356 amino acids)

>BT2119 transmembrane protein precursor, possibly involved in transport (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKRFNFLLTGILVVLLASCSQRTQITDSKPTVKIDTVLSAGGQTALQFPGRVKAAQDISL
SFRVSGTILRMYVNDGTYVRKGQLLAELDPADYQIQLDAAEAEYQSVKAEAERVMALYKE
NVTTPDANDKAMYGLKQITAKYNHAKDQLEYTRLYAPFSGYVQKRLFDSHETIAAGMPVV
SIISEGTPEVEINLPAVEYIRRQQFTGYTCTFDIYPGQEYALDLINVTPKANANQLYTMR
LQLKKGEAQALPSPGMNTMVTIECTEGEVRHLSVPTGAVLRDKGMASVFLYDASSRTIRR
CDVTVTRLLGSGRCLVTAEGLKPGDLIVASGVHHVKDGEQVEPLLPASKTNVGGLL