Protein Info for BT1966 in Bacteroides thetaiotaomicron VPI-5482

Annotation: multidrug resistance protein, AcrB/AcrD family (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1065 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 338 to 357 (20 residues), see Phobius details amino acids 364 to 386 (23 residues), see Phobius details amino acids 392 to 414 (23 residues), see Phobius details amino acids 435 to 456 (22 residues), see Phobius details amino acids 468 to 495 (28 residues), see Phobius details amino acids 540 to 558 (19 residues), see Phobius details amino acids 872 to 892 (21 residues), see Phobius details amino acids 899 to 919 (21 residues), see Phobius details amino acids 925 to 949 (25 residues), see Phobius details amino acids 971 to 992 (22 residues), see Phobius details amino acids 1006 to 1031 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1028 (1025 residues), 991.6 bits, see alignment E=4e-302 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 5 to 1033 (1029 residues), 1033.5 bits, see alignment E=0 PF03176: MMPL" amino acids 316 to 494 (179 residues), 39.4 bits, see alignment E=3.7e-14 amino acids 837 to 1026 (190 residues), 25.6 bits, see alignment E=6e-10

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_1966)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A6B8 at UniProt or InterPro

Protein Sequence (1065 amino acids)

>BT1966 multidrug resistance protein, AcrB/AcrD family (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MNLRTFIERPVLSAVISITIVVVGIIGLFSLPVEQYPDIAPPTIMVSTTYYGASAETLQK
SVIAPLEEAINGVEDMTYMTSTATNAGTVSITVYFKQGTDPDMAAVNVQNRVSRATGQLP
AEVTQVGVTTSKRQTSILQMFSLSSPDDSYDENFLSNYISINIKPQILRISGVGDLMIMG
GEYSMRVWMKPDVMAQYKLIPSDITGVLAEQNIESATGSFGENSNETYQYTMKYKGRLIT
PEEFGDIVIRSTDNGEVLKLKDIAEVQLGQDSYAYHGGMDGHPGVSCMVFQTAGSNATEV
NQNIDELLEEVRKDLPKGVELTQIMSSNDFLFASIHEVVKTLIEAIILVILVVYVFLQDF
RSTLIPLVGVIVSLIGTFAFMALAGFSINLLTLFALVLVIGTVVDDAIIVVEAVQARFDV
GYRSSYMASIDAMKGISNAVITSSLVFMAVFIPVSFMGGTSGTFYTQFGLTMAVAVGISA
INALTLSPALCALLLKPYINEDGTQKNNFAASFRKAFNSAFDILIEKYKNVVLIFIKRRW
LAWSLLVCSVVLLVFLMNTTKTSLVPDEDQGVVFVNVSTAAGSSLTTTDEVMERIEKRLM
DIPQIKHVQKVAGYGLLAGQGSSFGMLILKLKPWDERPNDEDNVQAVIGQVYGRTADIKD
ASVFAISPGMIPGYGMGNALELHMQDKMGGDINEFFTTTQQYLGVLNQRPEIAMAYSTFD
VRYPQWTVEVDAAKCKRAGITPDAVLSTLSGYYGGQYVSNFNRFSKVYRVMIQADPQFRL
DETSLDNAFVRMSNGEMAPLSQFVTLTRSYGAESLSRFNMYNSIAVNAMPADGYSTGDAI
KAVQETAVQSLPKGYGYDYGGITREENQQSGTTMIIFGICFLMIYLILSALYESFIIPFA
VLLSVPCGLMGSFLFAWMFGLENNIYLQTGLIMLIGLLAKTAILLTEYAAERRKAGMGLI
ASAVSAAKARLRPILMTALTMIFGLFPLMLSSGVGANGNRSLGTGVVGGMTIGTLALLFI
VPTLFIAFQWLQERLRPVQSRPTEDWQIEEEIKVSEEEKSKAGKK