Protein Info for BT1780 in Bacteroides thetaiotaomicron VPI-5482

Annotation: periplasmic beta-glucosidase precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details PF00933: Glyco_hydro_3" amino acids 206 to 453 (248 residues), 206.3 bits, see alignment E=1.7e-64 PF01915: Glyco_hydro_3_C" amino acids 498 to 729 (232 residues), 198.5 bits, see alignment E=2.5e-62 PF14310: Fn3-like" amino acids 763 to 831 (69 residues), 77.9 bits, see alignment 1e-25

Best Hits

KEGG orthology group: K05349, beta-glucosidase [EC: 3.2.1.21] (inferred from 100% identity to bth:BT_1780)

Predicted SEED Role

"Beta-glucosidase (EC 3.2.1.21)" in subsystem Beta-Glucoside Metabolism or Fructooligosaccharides(FOS) and Raffinose Utilization (EC 3.2.1.21)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.21

Use Curated BLAST to search for 3.2.1.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A6U6 at UniProt or InterPro

Protein Sequence (950 amino acids)

>BT1780 periplasmic beta-glucosidase precursor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKWILAVGLLSCSVAMAQQQSDILSVSASANAENAALAFDRNVKTMWTIPSQALKAEQWL
MFTIQQPGDVCELDLQMQGINKNELKEVLDIFVTYDPMNLGTPVNYRIEGSDKQMKVKFT
PKYGAHVKLNFKSGKLDKPFSLKEISVLVAEKVLTDSQGKVTDRRYMDASLPVEERVESL
LAVMTPEDKMELIREGWGIPGIPHLYVPPITKVEAVHGFSYGSGATIFPQALAMGATWNR
KLTEEVAMVIGDETVAANTKQAWSPVLDVAQDARWGRCEETFGEDPVLVSQIGGAWIKGY
QSRGLFTTPKHFGGHGAPLGGRDSHDIGLSEREMREIHLVPFRHAIRNYDCQSLMMAYSD
YMGVPVAKSKELLQQILRQEWGFNGFIVSDCGAIGNLTARKHYTAKDKIEAANQALAAGI
ATNCGDTYNNKEVIQAAKDGRINMEDLDNVCRTMLGTMFRNELFEKNPCKPLDWKKIYPG
WNSDSHKEMARQAARESIVMLENKDNLLPLSKTLRTIAVLGPGADDLQPGDYTPKLLPGQ
LKSVLTGIKGAVGKQTKVLYEQGCDFTNPDETNIPKAVKAASQSDVVIMVLGDCSTSEAT
NDVRKTCGENNDWATLILPGKQQELLEAVCATGKPVILILQAGRPYDILKASEMCKAILV
NWLPGQEGGPAMADVLFGDYNPAGRLPMTFPRHVGQLPLYYNFKTSGRRYEYVDMEYYPL
YRFGFGLSYTSFEYSNLKIQEKANGNVEVQATVKNVGSRAGDEVAQLYVTDMYASVKTRV
MELKDFARIHLQPGESKTVSFEMTPYDISLLNDRMDRVVEKGEFKIMVGGMSPDYVAKNE
IKHSVGYSDNKKGVTGMLNYTHEFGANFDLAVSKVEENLVKNQKTVWVSVKNTGTLMDIG
KVEMFVDGKKVGDAVHYELGAGEEKLIPFKLAKENKQPVAFTTKYKMVSM