Protein Info for BT1453 in Bacteroides thetaiotaomicron VPI-5482

Annotation: L-lactate permease (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 499 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 28 to 47 (20 residues), see Phobius details amino acids 54 to 78 (25 residues), see Phobius details amino acids 108 to 134 (27 residues), see Phobius details amino acids 143 to 165 (23 residues), see Phobius details amino acids 179 to 198 (20 residues), see Phobius details amino acids 210 to 228 (19 residues), see Phobius details amino acids 235 to 252 (18 residues), see Phobius details amino acids 273 to 293 (21 residues), see Phobius details amino acids 321 to 343 (23 residues), see Phobius details amino acids 364 to 390 (27 residues), see Phobius details amino acids 397 to 415 (19 residues), see Phobius details amino acids 479 to 498 (20 residues), see Phobius details PF02652: Lactate_perm" amino acids 2 to 497 (496 residues), 426 bits, see alignment E=2.4e-131 TIGR00795: transporter, lactate permease (LctP) family" amino acids 2 to 497 (496 residues), 405.1 bits, see alignment E=2.7e-125 PF03553: Na_H_antiporter" amino acids 241 to 498 (258 residues), 29.8 bits, see alignment E=3.9e-11

Best Hits

KEGG orthology group: K03303, lactate transporter, LctP family (inferred from 100% identity to bth:BT_1453)

Predicted SEED Role

"L-lactate permease" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A7S1 at UniProt or InterPro

Protein Sequence (499 amino acids)

>BT1453 L-lactate permease (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MTLILAIIPVLLLIVLMAFFKMSGDKSSIISLIVTMLIALFGFAFSVDNLFYSFLYGALK
AVSPILIIILMAIFSYNVLLKTEKMEIIKQQFASISTDKSIQVLLLTWGFGGLLEAMAGF
GTAVAIPAAILISLGFKPIFSATVSLIANSVATAFGAIGTPVLVLAKETNLDVLQLSTNV
VLQLSVLMFLIPLVLLFLTNPKLKALPKNIFLALLVGGVSLVGQYLAARYMGAESPAIIG
SILSIIVIVLYGKLTASKEEKARKSTLKTKDILNAWSIYLLILFLIILTSPLFPSLRSTL
ENNWVTRISLPVNATTVNYTISWLTHAGVLLFLGTFIGGLIQGAKVKELFIVLWNTVKQL
KKTFITVICLVGLSTIMDTSGMIAVIATALATATGSLYPLFAPVIGCLGTFITGSDTSSN
ILFGKLQASVAGQIHVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILKAA
IPYALAYVVITGIIVYIFS