Protein Info for BT1237 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 641 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 366 to 389 (24 residues), see Phobius details PF00512: HisKA" amino acids 419 to 483 (65 residues), 71.4 bits, see alignment E=5.1e-24 PF02518: HATPase_c" amino acids 530 to 637 (108 residues), 91 bits, see alignment E=6.9e-30

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_1237)

Predicted SEED Role

"Two-component system sensor histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A8D0 at UniProt or InterPro

Protein Sequence (641 amino acids)

>BT1237 two-component system sensor histidine kinase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MMRYIGCLFICLLWLFRATELFAVSNDQKPILIICSYNPAAHQTSVTISDYMEEYNKLGG
KRDIIIENMNCKSFSEAPLWSGMMTQILSKYQGEKHPAQIILLGQEAWAAYLSQRDSIQV
KVPVMCSLVSSNIVILPEDTVAGLDAWMPESVDLFTDHMNIPELKSGFINQYNIEDNVRM
IKAFYPKTEHIAFISDNTYGGVTMQALVRKEMKKFPEIDLILMDGRRHTIYTIVEELRHL
PENTVIMVGTWRVDMNEGYFMRNATYAMMEVTPTIPTFTPSSVSLGYWAIGGVLPDYRKL
GMDMALASVQIDRYPADEQQHLSVIGSKAVLDSRKVKEWGLDPDILPFDVQIINQTVSFY
QQYTYQIWSACALVVILVLGLCISLFYYFRTKRLKDDLLKSEKDLRVAKDRAEESNRLKS
AFLANMSHEIRTPLNSIVGFSDVLAVGGNTEEEQQTYYQIIKTNSDLLLRLINDILDLSR
LEANRVTLTWEECDVVQLCRQVVASVSVSRQSGNQFLFVSDYESFRMTTDIQRMQQVIIN
LMSNADKFTRKGQITLEFSVNEETEMAVFSVTDTGCGIPKEKQKLVFERFEKLNEYAQGT
GLGLSICKLIVHKWKGDIWIDSEYTGGARFMFSHPLKIEKE