Protein Info for BT0754 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1138 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF07660: STN" amino acids 57 to 106 (50 residues), 44.9 bits, see alignment (E = 2e-15) PF13715: CarbopepD_reg_2" amino acids 121 to 201 (81 residues), 64.6 bits, see alignment 1.7e-21 TIGR04056: TonB-linked outer membrane protein, SusC/RagA family" amino acids 121 to 1138 (1018 residues), 1002.1 bits, see alignment E=3.7e-305 PF13620: CarboxypepD_reg" amino acids 121 to 189 (69 residues), 46.5 bits, see alignment 9.5e-16 PF07715: Plug" amino acids 209 to 315 (107 residues), 72.6 bits, see alignment E=8.9e-24 TIGR04057: TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region" amino acids 291 to 321 (31 residues), 59.8 bits, see alignment (E = 1.7e-20) PF00593: TonB_dep_Rec_b-barrel" amino acids 555 to 1088 (534 residues), 65.2 bits, see alignment E=2.8e-21

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_0754)

Predicted SEED Role

"TonB family protein / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8A9R1 at UniProt or InterPro

Protein Sequence (1138 amino acids)

>BT0754 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MRLIIRKTLLMFLLLSLSNVLTGFQLSAQEQNKKFSVKADNVTLKEAIEVVRKQGNYSFL
IRNNDIDLNKKVSVNVDKGTINDVMAQLLTGTGISYEVNGNRVVIFHAAVPEKEQGKAFV
LKGKVTDPSGEGVIGANVKVLNSTEGTITDMDGNFSLSVTPNARLSVSYIGYATQEVVVK
NQTPLHIALKEDSRLIDEVVVVGYGVQKKANLTGAVSSVKMDEVLGDRPVVSVSDALKGA
MPGLQITGNSGRPGEEMSFNIRGVNSLDKNGKPLVLVDNVEMDINMLDPNDIESVTVLKD
AASSAIYGARAAFGVILITTKKGSDSTRLSINYSNNFSFSRPANMPRKATPLQTVQAYKD
MGTINYQSGQNVDTWLDLLKEYNANPSAYPDGYAMVDGLRYSLAETNLFDDMMETGFQQT
HNLSVGGGTKDISYRFSFGMVDENGVLASDKDAYKRYNVSSYIRSDVFSWITPELDIKYT
NSKSELPETSGGYGIWGAAVAFPSYFPIGTMNIDGEELPINTPRNLINLAYPTTIQKNNI
RIFGKVTITPLKNVKLVGEYTYNHLSNEKTKFEKKFYYAHGGNFVKETSTANSKYENSNG
ITDYNALNFYGNYNNTWGKHEVTVMGGFNQESSDYRYAEMSRMNMINEDLPSISQATGDY
FAKDKFERYTVRGLFYRINYSFAGKYLIETNGRYDGSSKFPKDSRFGFFPSVSAGWRVSE
EAFMKPLTSVLSNLKLRASWGNIGNQSITPYAYIPGMDAEQAYWTVSGIKVTTLKPAALV
SNSFTWEKVTTVDVGFDLGLLNNRLNLVFDWYRRDTKGMLAPGAELPAVLGASAPLQNTA
DLRSKGWEITVDWNDQIGKVKYNLGFNLYDAKTKITKYNNETGLFGKDKNDKDTYRVGME
LGEIWGYVTDRLYTVDDFDADGKLKAGIPKVEGYNPNPGDILYKDLDDNDIINGGTSTTK
DPGDRKIIGNSTRRYQYGIHGGANWKGVSLSFLLQGVGKRDLWIMNDLFYPHYDAWTTVY
DTQLNYWTPERTDSYFPRLYEKAAGNTAANTRIQTRYLQDGSYLSIRNITLSYNFPSKWM
TKIGVNNLAVFFSGENLYTFDHLPKGLDPERSVTDDLGQRGFTYPYMRQYSFGINLSF