Protein Info for BT0541 in Bacteroides thetaiotaomicron VPI-5482

Annotation: Polyphosphate kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 705 TIGR03705: polyphosphate kinase 1" amino acids 12 to 672 (661 residues), 801.7 bits, see alignment E=2.9e-245 PF13089: PP_kinase_N" amino acids 12 to 116 (105 residues), 108.7 bits, see alignment E=4.6e-35 PF02503: PP_kinase" amino acids 126 to 312 (187 residues), 151.8 bits, see alignment E=4.1e-48 PF17941: PP_kinase_C_1" amino acids 339 to 498 (160 residues), 202.7 bits, see alignment E=7.8e-64 PF13091: PLDc_2" amino acids 369 to 492 (124 residues), 32.2 bits, see alignment E=2.1e-11 PF13090: PP_kinase_C" amino acids 506 to 668 (163 residues), 212.3 bits, see alignment E=8.5e-67

Best Hits

KEGG orthology group: K00937, polyphosphate kinase [EC: 2.7.4.1] (inferred from 100% identity to bth:BT_0541)

Predicted SEED Role

"Polyphosphate kinase (EC 2.7.4.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism or Purine conversions (EC 2.7.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.1

Use Curated BLAST to search for 2.7.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AAC4 at UniProt or InterPro

Protein Sequence (705 amino acids)

>BT0541 Polyphosphate kinase (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKSSETKKKCPYVERDISWMYFNQRILLEAARPEVPLLERLTFLGIYSNNLDEFFRVRVA
TLNRIIEYADKNIQKEQETATRTLKQISKLHNRFYEQFEETFASIMEELKKENICVIKDT
EMTDDQKTFITSFYRNKLNGSTTPLFLNGARPLDDQTDEDIYLAIRLLRKDETGKIKEKD
YAVIELPTEEYGRFIQLPDSEGKTYLMFLDDVIRYCLPLIFVGMKYTDYEAYTFKFTKDA
EMEIDSDLRTGVLQKISKGVKSRKRGEPIRFVYDEQIPKDLLKRLVDRLNVDKNDTRVAG
GRYHNFKDLMKFPVCGRYDLKYPVWEPVFKPELNGKESLLTLIRQKDRSLHYPFHSFDTF
IRVLREAAISKEVKSIKMTLYRLAKESKVIKALICAAKNGKKVTVVIELLARFDEASNIN
WSKRMQDAGIHVIFGVEGLKIHSKLVHIGTRHGDIACISTGNFHEGNARMYTDYTIMTAH
RPLVREVNAVFDFIEKPYTPVNFKELLVSPNDMRKRLIALISKEIKNKEQGKEAYILAKV
NHITDRALIEKLYEASTAGVQVELVVRGNCSLVTGIAGISENIHINGIIDRYLEHSRIFI
FANGGEEKYYIGSADWMPRNLDNRIEVLAPVYDKEIQADLKRIVCYGYRDTAKGRIVDGT
GENRPWENRPSTLCKDFTPALAEAETATVVFRSQEELYRKYKNTL