Protein Info for BT0433 in Bacteroides thetaiotaomicron VPI-5482

Annotation: putative xylose repressor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 402 PF13412: HTH_24" amino acids 19 to 61 (43 residues), 29.9 bits, see alignment 3.4e-11 PF00480: ROK" amino acids 89 to 397 (309 residues), 199.2 bits, see alignment E=1.2e-62

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_0433)

Predicted SEED Role

"Mlc, transcriptional repressor of MalT (the transcriptional activator of maltose regulon) and manXYZ operon" in subsystem Maltose and Maltodextrin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AAN1 at UniProt or InterPro

Protein Sequence (402 amino acids)

>BT0433 putative xylose repressor (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MNQQFLKEIEMGSKNALVKKRIITHYIYNGSSTIPDLSKELDLSVPTVTKFIGEMCEDGY
INDYGKLETSGGRHPNLYGLNPESGYFIGVDIKRFAVNIGLINFKGDMVELKMNIPYKFE
NSIEGMNELCKLILNFIKKLPINKEKILNINVNVSGWVNPESGYSFSQFNFEERPLADVL
SEKLGHKVTIDNDTRAMTYGEYMQGCVKGEKDIIFVNVSWGVGIGIIIDGKVYTGKSGFS
GEFGHVNAYDNEIICHCGKKGCLETEASGSALHRILLERIKSGESSILSTRISGEEDPIT
LDEIITAVNKEDLLCIEIVEEIGQKLGKQIAGLINIFNPELVIIGGTLSLTGDYITQPIK
TAVRKYSLNLVNKDSAIITSKLKDKAGIVGACMLARSRMFES