Protein Info for BT0366 in Bacteroides thetaiotaomicron VPI-5482

Annotation: two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1420 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 809 to 829 (21 residues), see Phobius details PF07494: Reg_prop" amino acids 41 to 63 (23 residues), 18.2 bits, see alignment (E = 9.1e-07) amino acids 368 to 389 (22 residues), 19.5 bits, see alignment (E = 3.5e-07) amino acids 413 to 436 (24 residues), 19.5 bits, see alignment (E = 3.6e-07) amino acids 564 to 582 (19 residues), 15.3 bits, see alignment (E = 8e-06) amino acids 606 to 629 (24 residues), 27.3 bits, see alignment (E = 9.9e-10) PF07495: Y_Y_Y" amino acids 739 to 803 (65 residues), 66.3 bits, see alignment 8.2e-22 PF00512: HisKA" amino acids 904 to 967 (64 residues), 37.9 bits, see alignment (E = 6.5e-13) PF02518: HATPase_c" amino acids 1014 to 1133 (120 residues), 91.9 bits, see alignment E=1.6e-29 PF00072: Response_reg" amino acids 1169 to 1280 (112 residues), 88.2 bits, see alignment E=2e-28 PF12833: HTH_18" amino acids 1336 to 1416 (81 residues), 66.2 bits, see alignment 1.2e-21 PF00165: HTH_AraC" amino acids 1375 to 1417 (43 residues), 40 bits, see alignment (E = 1.4e-13)

Best Hits

KEGG orthology group: None (inferred from 100% identity to bth:BT_0366)

Predicted SEED Role

"two-component system sensor histidine kinase/response regulator, hybrid ('one component system')"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8AAU8 at UniProt or InterPro

Protein Sequence (1420 amino acids)

>BT0366 two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) (Bacteroides thetaiotaomicron VPI-5482)
MKKHLLIYLIIYSICSLAGQVRAQERFADRYNITYVTMNEGLPHNFIDDLYKDSRGFMWI
STAGGGLSRYDGYEFVNYTPNNHQCKLKSNFIRNVCEDAFQRLWIVSEGGTDIIDLSTLK
PIIPHDPKGILPKILELPATRIMKDTQGCIWLHCDNALHRIEFNDKGEVQILSTLSPVYL
NGPDIALKDIDEDGKIWMGNNGEIRKVALSPQKRLVTTPIADCLKFEAGTYISDFLSKEN
EVWISSDRGLFRYNKTGNVIKRYEHDSGNPYSLSQNYLTNLAITDDKQLIVATLRGINIY
NPMTDNFERIACDLPNGGTNLLNSNFINCILTDGEHIWFGTETGGINLLNPRQLSIRSYR
HDKENPSSLSYNPVNAIYEDVYGTLWVGTVEGGLNRKERNSEDFTHYTREHGGLSHNSVS
ALTADTDNHLWIGTWGGGLNLLDLKAPRQILEVISSQTGGGFPINFIGVLNYDPINEGIW
IGANQGLYFYDPVKKEITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEGVYIIDLHSRS
SKGEFQYRHLNYKLDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQRKIDAQGKEQFIS
YSTAQGLPNNSVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQDGLIDTQFYWNAS
CGSSHDLLYFGSVGGLVAIESNRPAMSLPAAKVRFTRLRIGNEEILPGSEYLSEDIAITT
ELKLHEKEKSFSLEFAALNFESNNTAIYSYRLVGFDDKWVQVPGNRRFASYTNLPPGSYT
LQVRYTPDGENEGENITELKITIVPYFYKTVWFILFIIVLLSVSVWQFYQWRIRNLKRQK
EYLHRTVEERTHELEQQKHLLENQTDELSRQNQMLIQQNEKITRQKAQLIRMSRKVQELT
LDKISFFTNITHEFRTPITLIIGPIERALKLSYNPQVIEQLNFVERNSKYLLSLVNQLMD
FRKVESGKLEIVKTRGNFLKFIDSLITPFEVFAQERNIVLKRYYRMEMPEILYDEEAMRK
VVTNLLSNAIKFTPNGGTVSLYLSALFAKDSEKETLYICVKDSGSGIPEEDLNRIFNRFY
QSQNQVKYPVYGQAGTGIGLYLCKRIVQMHGGEIKAFNNRHAGCSFRILLPLQRNERKDE
KTIIIDHNDSSATPVQDSGSPKEKEALSILVVEDNADMRGYIRSILREQYHVLEAANGEE
ALHILNSNPIDFIISDLMMPVMDGIELSRRVKETFAISHIPFLMLTAKTSQEARLESYRM
GVDEYLLKPFDETLLLARIQNILENRKRYQRKFTLDMDVDVLNMEEESGDKKFLNQVMEV
IKENYKNSYFEVSDFCEAVGVSKSLLNKKLQNLIGQSAGQFIRNYRLNIARELILKNRET
KNMNIAEVAYEVGFNDPKYFTRCFTKHFNVTPSALLNNEE