Protein Info for DVU0568 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: rhodanese-like domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 PF00581: Rhodanese" amino acids 10 to 129 (120 residues), 47 bits, see alignment E=1.5e-16 TIGR03167: tRNA 2-selenouridine synthase" amino acids 19 to 318 (300 residues), 379.4 bits, see alignment E=7.7e-118

Best Hits

KEGG orthology group: K06917, tRNA 2-selenouridine synthase [EC: 2.9.1.-] (inferred from 100% identity to dvu:DVU0568)

Predicted SEED Role

"Selenophosphate-dependent tRNA 2-selenouridine synthase" in subsystem Selenocysteine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.9.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72EL0 at UniProt or InterPro

Protein Sequence (346 amino acids)

>DVU0568 rhodanese-like domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPHIIDASTFLALRDTGLPVLDARSPSEHARGAIPGALNLPVLDDAQREAVGTLYARSGR
EAAVHLALQLVGPHLSAMLARAQHLCENRHEVLVHCWRGGMRSGSLAWLLESAGYTVHLL
EGGYKAYRAHVRAQLARPARVIVLGGMTGTGKTDILHAMADLGCQVVDLEGLANHRGSAF
GSIGLGKQPTNEQFEAALYEVWSRLDHGRPIWMEDESSRIGTVAMCDAFFTHIEHGRLVT
VELPLEARVARLVAEYAATGETEAMLHGLERIRKRLGDDAWRRCADALRAGDHTTAVRIL
LRYYDKAYAHHQAQQPREAVRHIVLERDDPATVARRLAADEDSLAG