Protein Info for DVU0508 in Desulfovibrio vulgaris Hildenborough JW710

Name: infB
Annotation: translation initiation factor IF-2 (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1079 TIGR00487: translation initiation factor IF-2" amino acids 495 to 1077 (583 residues), 846.7 bits, see alignment E=1.1e-258 PF04760: IF2_N" amino acids 504 to 553 (50 residues), 51.4 bits, see alignment 2.6e-17 TIGR00231: small GTP-binding protein domain" amino acids 580 to 737 (158 residues), 106.4 bits, see alignment E=1.3e-34 PF00009: GTP_EFTU" amino acids 582 to 737 (156 residues), 117 bits, see alignment E=2.9e-37 PF01926: MMR_HSR1" amino acids 583 to 688 (106 residues), 44.1 bits, see alignment E=7.1e-15 PF00071: Ras" amino acids 584 to 738 (155 residues), 26.6 bits, see alignment E=1.4e-09 PF00025: Arf" amino acids 585 to 737 (153 residues), 24.2 bits, see alignment E=7.4e-09 PF11987: IF-2" amino acids 853 to 969 (117 residues), 140.2 bits, see alignment E=1e-44 PF03144: GTP_EFTU_D2" amino acids 1000 to 1067 (68 residues), 30.7 bits, see alignment 1.2e-10

Best Hits

Swiss-Prot: 93% identical to IF2_DESVH: Translation initiation factor IF-2 (infB) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 93% identity to dvu:DVU0508)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72ER1 at UniProt or InterPro

Protein Sequence (1079 amino acids)

>DVU0508 translation initiation factor IF-2 (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTENKTKVKDLAAELGVTTKELGQVLKDMNISAKTSTSVIAQEDLPRIKERVQAQRDGGA
RKEGNPDVIVRRRHRDGDRASARAEAKAPEQEATAAMPETSAPERAEEADKPAVAKPAKA
PETEAHARARKEPQAEPVKARIIRRPDEPAPVAKVVEAAPAETPAPEAPAVKATVTAEAA
PAKTVEPESERPQADKPATARVVRPATPDASAVPDGTSSAPTLPVRSAEPSDTVERADAD
ADGDDDDAQQRRRKKKRRQPEAVVPQVRVISRPDPAAVAQQQMQQQAAQQQREAGGYRPG
GQRPEGGYRPEGQREGGYRPEGQREGGYRPGGAPRPEGGYRPGGPRPEGGYRPGAPRPEG
GYRPAGGPRPEGQREGGYRPGAPRPEGGYRPAGGAPRPEGQREGGYRPAGGPPRPGGAPR
PGGFGGAPGGMPVPGADGRGDQSKKKRQKGRRTVDFQADGPRGRSDDDVMRGPRGRGKRG
KKDVRPAATQPLKAVKRKIKVDEAIRVADMAHQMGLKANEIIKVLFGLGVMATINQSLDI
DTATVVAGEFGYEVEKVGFSEDDYLVPKEEDAPETLVTRPPVVTIMGHVDHGKTSLLDAI
RKSNVTAGEAGGITQHIGAYHVTTKKGEIVFLDTPGHEAFTAMRARGAQITDLVVLVVAA
DDGVMEQTREAVNHSKAAGVPIMVAVNKMDKEGANPDRVIRELSELGLVAEDWGGDTIFA
KVSAKTREGLDELLELIAIQAEILELKANPDKAARGHVVEAKLDKGRGPLATVLVQEGTL
RQGDAFVCGVFAGRVRAMFDDQGRKVKEAGPSTPVEVQGFDGVVEAGEEFVSVADDKVAR
RIAESRAVKQRERELAKESKVTLETFLSRRADAAEALTLNLVLKADVQGTLEAISEAVRK
LSTEKVKINIIHGGAGAITESDILLASASDAIIIGFNVRPTSKVKDIAEQENVDIRFYDI
IYKLVDEIKSAMAGMLAPVQREVYLGQAEVRETFSVPKIGVIAGCHVADGKVTRNAGVRL
LRDGVVVYTGKITSLKRFKDDVRDVQKGYECGMGLENFNDIKVGDVIEAFEMVEEAATL