Protein Info for DVU0453 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: ATP-dependent DNA helicase, UvrD/REP family (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1127 PF00580: UvrD-helicase" amino acids 544 to 769 (226 residues), 130.1 bits, see alignment E=2.7e-41 PF13245: AAA_19" amino acids 547 to 766 (220 residues), 83.4 bits, see alignment E=3.5e-27 PF13361: UvrD_C" amino acids 787 to 918 (132 residues), 28.5 bits, see alignment E=2.2e-10 amino acids 989 to 1079 (91 residues), 75.9 bits, see alignment E=8.4e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvu:DVU0453)

Predicted SEED Role

"ATP-dependent DNA helicase pcrA (EC 3.6.1.-)" in subsystem DNA repair, bacterial UvrD and related helicases (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72EW5 at UniProt or InterPro

Protein Sequence (1127 amino acids)

>DVU0453 ATP-dependent DNA helicase, UvrD/REP family (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MQQFRADLHIHSRFSRATSSRLNARHLAAWAAVKGIDVLGTGDFTHPQWLAELREQLVRD
DASGLYRLRDPRGLSDELPAFADRVKQSRCLFVPQAEISSIYKRGGKVRKVHNIVYMPDF
DAVDRLNRKLAEVGNLVSDGRPILGLDARDLLGMVLDADPRGVLVPAHIWTPWFAVFGSK
SGFDTLDDCFGDLTGEIFALETGLSSDPEMNWLWSHLDRFALISNSDAHSGDNLGREANL
FEGEMSYDGIFRSLRGDAVDCRFLGTLEFFPEEGKYHLDGHRACNVVYEPRETVARGGLC
PVCGKPLTVGVLHRVLELADRDTPEQVAGRQGFRSLIPLPEILGEILGVGAKSRKVADWT
GRLVQRFGPELAILQDVSLDALRRYWEPLGEGIARMRRGEVLRQGGYDGEYGVVRVFTER
ERASLRGGGGSKAALPLLDLGGAASAPAVHDTPGRRNTGTKDAGAGGIISPAVAGADVAT
SAKASGGRAASASEAGGANASAETTTPHDTTAVRQTSADGGGEGPGLASLFISARPAEPP
VDFNPEQRSAIAGGPGPVLVLAGPGTGKTRTLVGRVQRLVAEGVAARRIVAVTFTRRAAT
EMDERLSVTLGDGAPLPRTDTLHALAFEFWHRSSAQPPVLLSEEAARRVFAEANPDATAQ
TLREAWDELAVCRERMQVCSLALAPLLDRYVQQKAAWNLADYTDLLEFWLEQIHNGLYVP
PWRHVLVDEIQDLSPLQLALVRALLPPGGEGFFGIGDPDQSIYGFRGAHGDVKGALDEAW
PGLSVVTLRANYRSSASVLDAAGALMEGRSACGRLRAVRDLPADIRLFEAPSAESEAAWI
GDRIRSLIGSTAHTLVDAAPEGALPGEGTFGPGDIAVLVRVRALIPVLQRTLSRLGVPVA
APETEAFWADQRVSLILAAAGRFVGIGSAVAGGPGDEVNCPDKMLARGPLGVAAYLRESP
PFDELFWQSAAFKALSKAYDTHGGWVGLINWVNLQSELETVRRRSEKVQVMSLHAAKGLE
FRAVFLPALEDGILPFAGAATLSGHADREHMRTDLEEERRLFYVGITRAAEGLYLSRASR
RTLYGREVRLKASRFLDDVPVAGVKRSALVRHSKHSVKQLSLLGGGD