Protein Info for DVU0422 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: sensory box/GGDEF domain/EAL domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1072 PF08448: PAS_4" amino acids 120 to 204 (85 residues), 27.7 bits, see alignment E=8.4e-10 amino acids 245 to 355 (111 residues), 47.4 bits, see alignment E=6.1e-16 amino acids 516 to 620 (105 residues), 23.2 bits, see alignment E=2.1e-08 TIGR00229: PAS domain S-box protein" amino acids 389 to 504 (116 residues), 43.8 bits, see alignment E=2.6e-15 amino acids 503 to 625 (123 residues), 60.9 bits, see alignment E=1.3e-20 PF13188: PAS_8" amino acids 393 to 448 (56 residues), 29.8 bits, see alignment 1.3e-10 PF13426: PAS_9" amino acids 402 to 495 (94 residues), 24.2 bits, see alignment E=1e-08 amino acids 516 to 618 (103 residues), 54.6 bits, see alignment E=3.4e-18 PF00989: PAS" amino acids 507 to 616 (110 residues), 45.5 bits, see alignment E=2.1e-15 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 628 to 789 (162 residues), 136.2 bits, see alignment E=8.6e-44 PF00990: GGDEF" amino acids 631 to 786 (156 residues), 148.2 bits, see alignment E=5.5e-47 PF00563: EAL" amino acids 808 to 1041 (234 residues), 230.5 bits, see alignment E=5.9e-72

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvu:DVU0422)

Predicted SEED Role

"sensory box/GGDEF domain/EAL domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72EZ6 at UniProt or InterPro

Protein Sequence (1072 amino acids)

>DVU0422 sensory box/GGDEF domain/EAL domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MFPNGGHMRLSPEGSQSPRTLQTAEATNFAVLRVGVDGVVRHADASGEALLGEVCGVRLE
TVLQTTPRTPVPPWSGNALLLCREGPTACRATFTSLPGEDGLLVCLDLTPPSADTLLSLR
HSGLPVALRDADSIFRFVSPAFAALFGIPERAFRNAPPESVLPKSSARALRQADRATLLR
MEAHAHTIPLSAEEQPVRCTSIPLPRTAWGTAVLSIVLHTDDDTFAPDVDPASGMGPYAP
WQILLDEMPGLLALTDFEGRVQLLNKAGHTLLRLPDGIARGRHRAELLPERIAALLAADN
ERMQREGTPSQLEVTLPRYGHDGSDRTFLVQRFPVRDHSGGMQGVGTVAMEISALKNTEA
GLRQRLTNIEAMVATRTEELRVANEALHRSSTRFRALFDYAPDGLLLQRDDGTLLDCNRM
AEATLGLSRHELLALKARDICREGHALPVPESEDTPLRTRTELLRGGVAFPAEVSVRSLD
IEGERTLLVALRDISSRIHTEHRLNLFELVFRNALEGILITDASGAILAVNPAFTTITGW
NERDAVGRNPRILKSNRHDRGFYERLWHSLHERGAWEGEIWNRRINGENYPEWLSISAIR
DESGATTNYVALFHDISDLKAKEAQIRYQGMHDALTGLPNRALLLERLAGELKEGQGTGR
LCGLLYIDIDNFKTINDSLGHEAGDKFIAEVAEHLTLLIRPEDTLSRLGGDEYVILVANP
GEEREVVLVAERILHHFSQPIALLDRELHVGLSIGIAIHPADGKGPDELLTNADLAMYRA
KAQGKNTYERFSPHLHDRIRSRMELEGRLRHALRHGEIVPHFQPRVDLATGRIVGAEALA
RWTLPDGTRISPGEFIPVAEDLGLIFDLGEHMLRSSLAFTRALMDEGLPDITMAVNLSLV
QCRHADLVGRVLAALRDTGVPPERLELEITESAIMSDVTRTLRRLDRLAALGITLAVDDF
GTGYSSLYHLKHMPLHTLKIDQSFVRDLPHVAGSRTIALTMLAMARNLDLDVIAEGVETG
AQMHFLRDHGCRVVQGFLFSPAVPGDRLFDLLRRGVCFDVNVAPGELSFDHP