Protein Info for DVU0160 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: carbohydrate isomerase, KpsF/GutQ family (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 331 PF01380: SIS" amino acids 47 to 175 (129 residues), 93.2 bits, see alignment E=1.2e-30 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 49 to 317 (269 residues), 312 bits, see alignment E=1.9e-97 PF00571: CBS" amino acids 205 to 261 (57 residues), 26.3 bits, see alignment E=7.5e-10 amino acids 271 to 322 (52 residues), 43.9 bits, see alignment 2.5e-15

Best Hits

Swiss-Prot: 44% identical to KDSD_PSEAE: Arabinose 5-phosphate isomerase KdsD (kdsD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 100% identity to dvl:Dvul_2808)

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72FQ3 at UniProt or InterPro

Protein Sequence (331 amino acids)

>DVU0160 carbohydrate isomerase, KpsF/GutQ family (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTDDQIHQTDWLQRGRDVLDIEAEGIRAVRDRLGPSFESALALLAGCRGRVVVTGLGKSG
LVGRKLAATFSSTGSPAFFLHPVEGAHGDMGSLKADDVVIAISNSGETDELNAILPSLRA
IGTPIIALTGRADSSLGRGADIVLDCGVPREACPLGLAPTASTTAVLALGDALAVCLIDW
KSFTENDFLRYHPGGSLGQRLRLRVAELMHTEGIPVVNEEAVCEEAVLALDKGGFGAVAL
TDGGGRLTGILTDGDVRRAVLRGTYGPRVGVTHIMTRNPRFARQTQSVAELIDIMEQKAI
TVLPITDDDHRLVGLVHLHDLLGKGGVTFAG