Protein Info for DVU0013 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: sensory box histidine kinase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 175 to 197 (23 residues), see Phobius details PF00672: HAMP" amino acids 193 to 244 (52 residues), 36.7 bits, see alignment 1.3e-12 TIGR00229: PAS domain S-box protein" amino acids 252 to 366 (115 residues), 24.7 bits, see alignment E=1e-09 PF13188: PAS_8" amino acids 256 to 289 (34 residues), 24.6 bits, see alignment (E = 5.4e-09) PF00989: PAS" amino acids 256 to 358 (103 residues), 23.7 bits, see alignment E=1.3e-08 PF08448: PAS_4" amino acids 262 to 362 (101 residues), 29.4 bits, see alignment E=2.4e-10 PF00512: HisKA" amino acids 368 to 433 (66 residues), 64.2 bits, see alignment E=2.7e-21 PF02518: HATPase_c" amino acids 480 to 593 (114 residues), 91.6 bits, see alignment E=1.3e-29

Best Hits

KEGG orthology group: K07636, two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC: 2.7.13.3] (inferred from 100% identity to dvl:Dvul_2950)

Predicted SEED Role

"Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72G47 at UniProt or InterPro

Protein Sequence (602 amino acids)

>DVU0013 sensory box histidine kinase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MNGMRSSLRKRLVLGTWLLLLMALAPPFVYFDRTIREDMLEEARKRATETLSSTQWVLSR
HAPFGSEDALEAWAVEYARHTGVRFTYIVDGKVMADSDVPAERVHLMDDHGGRPEVVAAS
RGGSGMEVRYSTTLRKDLVYAALRVEGIAGLPAGVIRVALPVSEVRDRIDSMETGLLWAF
IFSLLASGGLGFLVTRPFLGGIESMARAAQAIGQGDYGRRIRDIPGRELRPLAHAINGMA
HNIERHLAVLEEQKGRLEAVFNGMREGVMVLDAEGRITTINRALTTMFEGIVSKIGRTPL
EATMKPELQRAVDDLRAKDTTEGRAIMLELSDGRAFEVNLVPFFDEAGRCVVLVFHDVSE
REKLERIRRDFVANVSHELKTPLTSIKGYAETLLESPPASCEQAGAFMRTILKNANHMTK
MVNSLLVLARSEHKGEKRVLAEVDAAEVLRQTLREFQPVARRKAIELVCEVEGAVTVMAD
RDGLGEVFRNLMDNAMKYSPEGTRVSVSARPGAGVATFCFRDEGPGIPENSKERIFERFY
RIEREGDTSKEGSAGLGLAICRRIVRSHGGEIWVESPLDPATRRGAAFFITLNTPRARVG
VV