Protein Info for DVU3336 in Desulfovibrio vulgaris Hildenborough JW710

Name: kdpD
Annotation: potassium channel histidine kinase domain protein/universal stress protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 PF02702: KdpD" amino acids 13 to 218 (206 residues), 291.9 bits, see alignment E=2.4e-91 PF00582: Usp" amino acids 243 to 357 (115 residues), 27.1 bits, see alignment E=5.4e-10

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to dvl:Dvul_0056)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725T9 at UniProt or InterPro

Protein Sequence (379 amino acids)

>DVU3336 potassium channel histidine kinase domain protein/universal stress protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDDFSEILARKRQGSLKVYLGYAAGVGKTYAMLQEAHRLAREGLDVVIGYVEPHDRADTL
ALVEGLEQVAPRKVAIAGSDFTEMDVPGIIARRPQVVLVDELAHTNAAGSENGKRYQDVL
KVLEAGINVITTLNVQHLESVAERVESVAGVRVQERLPDAILRRADQVVNVDLTKEDLRE
RLRQGRIYSPEQAERALGGFFSYRNLSFLRELCLREASGDQVRKIEEQEHFPRHSAGDVI
EGVMVALSSSPTDAETLIRRGVRIAHQMGSPCYVVYVQRPSENPTRIDSGLQRVLQGNLR
LATQLGAEVVQLAGGDIAETLANFASERNVRHAVFGKSRLSPLLERVRGSFILEFLHDAV
GVDVHIVNTTPRQPGQERA